...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons
【24h】

Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons

机译：与老年人中的微粒空气污染成分相关的脉冲压力的急剧变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An increased pulse pressure (difference between systolic and diastolic blood pressure) suggests aortic stiffening. The objective of this study was to examine the acute effects of both particulate matter (PM) mass and composition on blood pressure, among elderly persons. We carried out a panel study in persons living in elderly homes in Antwerp, Belgium. We recruited 88 non-smoking persons, 70% women with a mean age of 83 years (standard deviation: 5.2). Blood pressure was measured and a blood sample was collected on two time points, which were chosen so that there was an exposure contrast in ambient PM exposure. The elemental content of the collected indoor and outdoor PM_(2.5) (particulate matter with an aerodynamic diameter < 2.5 μm) mass concentration was measured. Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) on outdoor PM_(10) (particulate matter with an aerodynamic diameter < 10 urn) were measured. Each interquartile range increase of 20.8 ug/m3 in 24-h mean outdoor PM_(2.5) was associated with an increase in pulse pressure of 4,0 mraHg (95% confidence interval: 1.8-6.2), in persons taking antihypertensive medication (n = 57), but not in persons not using antihypertensive medication (n = 31) (p for interaction: 0.02). Vanadium, iron and nickel contents of PM_(2.5) were significantly associated with systolic blood pressure and pulse pressure, among persons on antihypertensive medication. Similar results were found for indoor concentrations. Of the oxy-PAHs, chrysene-5,6-dione and benzo[a]pyrene-3,6-dione were significantly associated with increases in systolic blood pressure and pulse pressure. In elderly, pulse pressure was positively associated with acute increases in outdoor and indoor air pollution, among persons taking antihypertensive medication. These results might form a mechanistic pathway linking air pollution as a trigger of cardiovascular events.
机译：脉压升高（收缩压和舒张压之间的差异）提示主动脉硬化。这项研究的目的是检查老年人中颗粒物质量和成分对血压的急性影响。我们对比利时安特卫普的老年人住房进行了小组研究。我们招募了88名非吸烟者，其中70％为女性，平均年龄为83岁（标准差：5.2）。测量血压并在两个时间点收集血液样本，选择这些时间点以使环境PM暴露存在暴露对比。测量了收集的室内和室外PM_（2.5）（空气动力学直径<2.5μm的颗粒物）质量浓度的元素含量。测量了室外PM_（10）（空气动力学直径<10 um的颗粒物）上的氧化多环芳烃（oxy-PAHs）。在服用降压药的人群中，平均室外PM_（2.5）的每四分位数间距增加20.8 ug / m3，与脉搏压力增加4,0 mraHg（95％置信区间：1.8-6.2）相关。 = 57），但未使用降压药的患者则不适用（n = 31）（相互作用的p为0.02）。在服用降压药的人群中，PM_（2.5）的钒，铁和镍含量与收缩压和脉压显着相关。对于室内浓度也发现了类似的结果。在氧基-PAHs中，-5,6-二甲基ch和3,6-二苯并[a] py与收缩压和脉压的升高显着相关。在老年人中，服用降压药的人中，脉压与室外和室内空气污染的急剧增加呈正相关。这些结果可能形成一种机制途径，将空气污染与心血管事件的触发联系起来。

著录项

  • 来源
    《Environmental research》 |2012年第8期|p.60-67|共8页
  • 作者

    Lotte Jacobs; Anna Buczynska; Christophe Walgraeve; Andy Delcloo; Sanja Potgieter-Vermaak; Rene Van Grieken; Kristof Demeestere; Jo Dewulf; Herman Van Langenhove; Hugo De Backer; Benoit Nemery; Tim S. Nawrot;

  • 作者单位

    Occupational and Environmental Medicine, Unit of Lung Toxicology, K.U.Leuven, Leuven, Belgium;

    Royal Meteorological Institute, Brussels, Belgium;

    Research group EnVOC, Department of Sustainable Organic Chemistry and Technology, Ugent, Cent, Belgium;

    Royal Meteorological Institute, Brussels, Belgium;

    Departement of Chemistry, UA, Wilrijk, Belgium,Molecular Science Institute, School of Chemistry, University of Witwatersrand, Johannesburg, South Africa,Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;

    Departement of Chemistry, UA, Wilrijk, Belgium;

    Research group EnVOC, Department of Sustainable Organic Chemistry and Technology, Ugent, Cent, Belgium;

    Research group EnVOC, Department of Sustainable Organic Chemistry and Technology, Ugent, Cent, Belgium;

    Research group EnVOC, Department of Sustainable Organic Chemistry and Technology, Ugent, Cent, Belgium;

    Royal Meteorological Institute, Brussels, Belgium;

    Occupational and Environmental Medicine, Unit of Lung Toxicology, K.U.Leuven, Leuven, Belgium,Research Unit of Lung Toxicology, Laboratory of Pneumology, Herestraat 49 (O&N1—box 706), B-3000 Leuven, Belgium;

    Occupational and Environmental Medicine, Unit of Lung Toxicology, K.U.Leuven, Leuven, Belgium,Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    particulate matter; elemental composition; oxygenated polycyclic aromatic; hydrocarbons; pulse pressure;

    机译：颗粒物元素组成氧化多环芳烃;碳氢化合物脉压;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号