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No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992

机译：英格兰北部，1962年至1992年期间，怀孕期间环境中的颗粒物暴露与死产风险之间没有关联

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摘要

Objectives: Research evidence suggests that exposure to ambient air pollutants can adversely affect the growth and development of the foetus and infant survival. Much less is known regarding the potential for an association between black smoke air pollution and stillbirth risk. This potential association was examined using data from the historical cohort UK Particulate Matter and Perinatal Events Research (PAMPER) study.rnMethods: Using data from paper-based neonatal records from the two major maternity hospitals in Newcastle upon Tyne (UK), a birth record database of all singletons born during 1961-1992 to mothers resident in the city was constructed. Weekly black smoke levels were obtained from routine data recorded at 20 air pollution monitoring stations over the study period. A two-stage statistical modelling strategy was used, incorporating temporally and spatially varying covariates to estimate black smoke exposure during each trimester and for the whole pregnancy period for each individual pregnancy. Conditional logistic regression models, with stratification on year of birth, were used to assess potential associations between black smoke exposures in pregnancy and stillbirth risk.rnResults: The PAMPER database consists of 90,537 births, between 1962 and 1992, with complete gestational age and residential address information, of which 812 were stillborn. There was no association between black smoke exposures in any trimester or across whole pregnancy and risk of stillbirth. Adjustment for potential confounders did not alter these results.rnConclusions: While black smoke in pregnancy is likely to be related to other pregnancy outcomes, our findings do not suggest that black smoke air pollution exposure during pregnancy increases the risk of stillbirth.
机译：目的：研究证据表明，暴露于环境空气污染物会对胎儿的生长发育和婴儿存活率产生不利影响。关于黑烟空气污染与死胎风险之间的潜在联系，人们知之甚少。方法：使用泰恩河畔纽卡斯尔（英国）两所主要产科医院的纸质新生儿记录数据（出生记录），利用历史队列英国颗粒物和围产期事件研究（PAMPER）研究的数据检查了这种潜在关联。建立了1961-1992年间出生于城市居民母亲的所有单身人士的数据库。在研究期间，从20个空气污染监测站记录的常规数据获得每周黑烟水平。使用了两阶段统计建模策略，该方法结合了时空变化的协变量，以估计每个孕期以及每个怀孕期间整个怀孕期间的黑烟暴露。结果：PAMPER数据库由1962年至1992年之间的90,537名出生者组成，具有完整的胎龄和居住地址，并采用了条件logistic回归模型（按出生年份进行分层）来评估怀孕期间黑烟暴露与死产风险之间的潜在关联。信息，其中812个死胎。在任何孕期或整个妊娠期间黑烟暴露与死产风险之间均无关联。结论：虽然怀孕期间的黑烟可能与其他妊娠结局有关，但我们的研究结果并不表明怀孕期间的黑烟暴露于空气中会增加死产的风险。

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  • 来源
    《Environmental research》 |2010年第1期|118-122|共5页
  • 作者

    M.S. Pearce; S.V. Glinianaia; J. Rankin; S. Rushton; M. Charlton; L. Parker; T. Pless-Mulloli;

  • 作者单位

    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK;

    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK;

    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK;

    Institute for Research in Environment and Sustainability, Newcastle University, UK;

    National Centre for Geocomputation, National University of Ireland, Maynooth, Ireland;

    Departments of Medicine and Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada;

    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK;

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  • 正文语种 eng
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  • 关键词

    air pollution; black smoke; epidemiology; particulate matter; stillbirth;

    机译：空气污染;黑烟;流行病学颗粒物死胎;

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