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首页> 外文期刊>Environmental research >Mercury exposure, serum antinuclear/antinucleolar antibodies,and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study
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Mercury exposure, serum antinuclear/antinucleolar antibodies,and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study

机译：巴西亚马逊地区采矿人群的汞暴露，血清抗核/抗核抗体和血清细胞因子水平：一项横断面研究

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摘要

Mercury is an immunotoxic substance that has been shown to induce autoimmune disease in rodent models, characterized by lymphoproliferation, overproduction of immunoglobuiin (IgG and IgE), and high circulating levels of auto-antibodies directed at antigens located in the nucleus (antinuclear auto-antibodies, or ANA) or the nucleolus (antinucleolar auto-antibodies, or ANoA). We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well controlled. The goal of this study is to specifically test whether occupational and environmental conditions (other than mercury exposure) that are associated with artisanal gold mining affect the prevalence of markers of autoimmune dysfunction. We measured ANA, ANoA, and cytokine concentrations in serum and compared results from mercury-exposed artisanal gold miners to those from diamond and emerald miners working under similar conditions and with similar socio-economic status and risks of infectious disease. Mercury-exposed gold miners had higher prevalence of detectable ANA and ANoA and higher titers of ANA and ANoA as compared to diamond and emerald miners with no occupational mercury exposure. Also, mercury-exposed gold miners with detectable ANA or ANoA in serum had significantly higher concentrations of pro-inflammatory cytokines IL-1β, TNF-α, and IFN-γ in serum as compared to the diamond and emerald miners. This study provides further evidence that mercury exposure may lead to autoimmune dysfunction and systemic inflammation in affected populations.
机译：汞是一种免疫毒性物质，在啮齿动物模型中已显示出可诱发自身免疫性疾病，其特征是淋巴增殖，免疫球蛋白（IgG和IgE）过量产生以及针对位于细胞核上抗原的高循环水平自身抗体（抗核自身抗体）或ANA）或核仁（抗核仁自身抗体或ANoA）。我们已经报道了手工金矿开采中暴露于汞的人群中ANA和ANoA的水平升高，尽管其他混杂变量也可能调节ANA / ANoA的水平没有得到很好的控制。这项研究的目的是专门测试与手工金矿开采有关的职业和环境条件（汞暴露除外）是否影响自身免疫功能障碍标志物的流行。我们测量了血清中的ANA，ANoA和细胞因子浓度，并将暴露于汞的手工金矿工的结果与在类似条件下，具有相似社会经济地位和传染病风险的钻石和绿宝石矿工的结果进行了比较。与没有职业汞暴露的钻石和翡翠矿工相比，暴露于汞的金矿工的可检出ANA和ANoA患病率更高，而ANA和ANoA的滴度更高。此外，与钻石和绿宝石矿工相比，血清中可检测到ANA或ANoA的汞暴露金矿工血清中的促炎细胞因子IL-1β，TNF-α和IFN-γ的浓度明显更高。这项研究提供了进一步的证据，表明汞暴露可能会在受影响的人群中导致自身免疫功能障碍和全身性炎症。

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  • 来源
    《Environmental research》 |2010年第4期|345-354|共10页
  • 作者

    Renee M. Gardner; Jennifer F. Nyland; Ines A. Silva; Ana Maria Ventura; Jose Maria de Souza; Ellen K. Silbergeld;

  • 作者单位

    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA;

    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA University of South Carolina School of Medicine, Department of Pathology, Microbiology & Immunology, Columbia, SC 29209, USA;

    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA;

    Institute Evandro Chagas (IEC), Fundacao National da Saude, Belem do Para 66090, Brazil;

    Institute Evandro Chagas (IEC), Fundacao National da Saude, Belem do Para 66090, Brazil;

    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA;

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  • 正文语种 eng
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  • 关键词

    mercury; autoimmunity; inflammation; antinuclear/antinucleolar autoantibodies; cytokines;

    机译：汞;自身免疫炎;抗核/抗核自身抗体;细胞因子;

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