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Early life environment, neurodevelopment and the interrelation with atopy

机译：早期生活环境，神经发育以及与特应性的关系

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摘要

Both neurological and immunological systems are vulnerable to early life exposures. Neurological disorders and atopy have been related in animals and humans. Our main objective was to assess whether multiple exposures to early life determinants remain associated with neurodevelopment after considering the potential intermediate role of atopy. A second objective was to assess whether genes associated with atopy may inform about the potential neurotoxical mechanisms.rnChildren were members of the AMICS birth cohort in Menorca (n=418, 87% of the recruited). General cognition was measured with the McCarthy Scales at age 4 and atopy through specific IgE at age 4 and prick test at age 6; 85 single nucleotide polymorphisms (SNPs) in 16 atopy and detoxification genes were genotyped.rnAmong the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO_2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition. These associations were apparently not mediated by the relation between atopy and general cognition. Among the candidate atopic genes, variants in NQ01 (a detoxification gene) and NPRS1 (related with affective disorders like anxiety and stress management) had a significant association with general cognition (p-value < 0.001). However, adjustment for the corresponding SNPs did not change the association between the early life determinants and general cognition.rnMultiple environmental pre-natal exposures were associated with neurodevelopment independently of their role in the immunological system. Atopic genes related to neurodevelopment suggest some potential mechanisms.
机译：神经系统和免疫系统都容易受到早期生命的影响。在动物和人类中，神经系统疾病和特应性疾病都有相关性。我们的主要目标是在考虑到特应性的潜在中间作用后，评估多次暴露于生命早期决定因素是否仍与神经发育相关。第二个目标是评估与特应性相关的基因是否可能提示潜在的神经毒性机制。儿童是梅诺卡岛AMICS出生队列的成员（n = 418，占新兵的87％）。一般认知是在4岁时用McCarthy量表测量的，在4岁时通过特异性IgE来进行特应性过敏，在6岁时进行点刺测试。对16个特应性和排毒基因中的85个单核苷酸多态性（SNP）进行了基因分型。在评估的27个风险因素中，母亲社会阶层较低，孕妇在怀孕期间吸烟，初生，母乳喂养时间较短，脐带血DDT水平较高以及室内较高NO_2（GSTP1多态性非排毒剂）水平与较差的认知能力独立相关。这些联系显然不是由特应性和一般认知之间的关系来介导的。在候选的特应性基因中，NQ01（一种排毒基因）和NPRS1（与诸如焦虑和压力处理等情感障碍有关）的变异与一般认知有显着关联（p值<0.001）。但是，调整相应的SNPs并不会改变早期生命决定因素与一般认知之间的联系。产前多次环境暴露与神经发育相关，而与它们在免疫系统中的作用无关。与神经发育有关的特应性基因提示了一些潜在的机制。

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  • 来源
    《Environmental research》 |2010年第7期|p.733-738|共6页
  • 作者

    J. Sunyer; X. Basagana; J.R. Gonzalez; J. Julvez; S. Guerra; M. Bustamante; R. de Cid; J.M. Anto; M. Torrent;

  • 作者单位

    Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Department of Experimental and Health Sciences, University of Pompeu Fabra, Barcelona, Spain;

    rnCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain;

    rnCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain;

    rnCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain;

    rnCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain;

    rnCIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Genes and Disease Program, Centre for Cenomic Regulation (CRG), Barcelona, Spain;

    rnGenes and Disease Program, Centre for Cenomic Regulation (CRG), Barcelona, Spain;

    rnCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Institut Municipal d'Investigacio Medica (IMIM)-Hospital del Mar, Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Department of Experimental and Health Sciences, University of Pompeu Fabra, Barcelona, Spain;

    rnCIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Menorca Health Area, Ib-Salut, Menorca, Spain;

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  • 正文语种 eng
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  • 关键词

    neurodevelopment; atopy; genes; DDT; NO_2;

    机译：神经发育特应性基因滴滴涕;NO_2;

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