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首页> 外文期刊>Environmental research >Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or not?
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Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or not?

机译：在环境和职业中汞暴露人群中，头皮头发作为生物标志物：是否合适？

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Hair is a well-established and widely used matrix for measuring mercury exposure of an individual. Although a variety of washing procedures to remove external mercury contamination have been proposed, no standardized procedures are available yet. In this study, different washing reagents like L-cysteine (Cys), 2-mercaptoethanol (ME), and disodium diaminoethanetetra acetate (EDTA) were used to find out if it is possible to remove mercury contamination from human scalp hair spiked with HgCl_2 solutions at different concentrations. It was found that the external mercury contamination could not be fully washed off even using reagents with high affinity to mercury like L-cysteine and ME. However, for the well-pulverized CRM hair samples some of the endogenous mercury was washed off. It suggests that hair is not a suitable biomarker for evaluation of total mercury exposure especially in people like mercury miners or gold miners/burners associated with serious external Hg exposure. However, hair still can be used as an indicator for methyl mercury exposure because, generally, there is almost no exogenous contamination of methyl mercury in hair.
机译：头发是用于测量个人汞暴露的公认且广泛使用的矩阵。尽管已经提出了各种去除外部汞污染的洗涤程序，但是尚无标准化程序。在这项研究中，使用了不同的洗涤试剂，例如L-半胱氨酸（Cys），2-巯基乙醇（ME）和二氨基乙烷四乙酸二钠二钠（EDTA），以确定是否有可能去除掺有HgCl_2溶液的人头皮头发中的汞污染在不同的浓度。发现即使使用对汞具有高度亲和力的试剂（如L-半胱氨酸和ME）也无法完全清除外部汞污染。但是，对于经过充分粉碎的CRM头发样品，一些内源性汞被洗掉了。这表明头发不是评估总汞暴露的合适生物标志物，特别是在汞矿工或金矿工/燃烧器等与外部汞接触严重相关的人群中。但是，头发仍然可以用作甲基汞暴露的指标，因为通常，头发中几乎没有外源性甲基汞污染。

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