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首页> 外文期刊>Environmental Science & Technology >Human Sex Hormone Disrupting Effects of New Flame Retardants and Their Interactions with Polychlorinated Biphenyls, Polybrominated Diphenyl Ethers, a Case Study in South China
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Human Sex Hormone Disrupting Effects of New Flame Retardants and Their Interactions with Polychlorinated Biphenyls, Polybrominated Diphenyl Ethers, a Case Study in South China

机译：新型阻燃剂对人性激素的破坏作用及其与多氯联苯，多溴联苯醚的相互作用，以中国南方为例

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摘要

Even though sex hormone disrupting effects of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are widely understood, similar effects associated with new flame retardants (NFRs) have not been so well studied. This study aimed to explore the sex hormone disruption of NFRs and their interactions with PCBs and PBDEs through the conduct of an ecological study in an e-waste dismantling and control region in South China. Questionnaires and blood samples were collected from local adult residents. Results of generalized additive model and linear regression analyses indicate that several species of NFRs showed similar disrupting effects with PBDE congeners on female follicle-stimulating hormone (FSH) and male testosterone. Judged by the curved shape and statistical significance, Sigma NFR (sum of 8 species of NFRs) showed stronger disrupting effects on male testosterone and female FSH compared to Sigma PBDE (sum of 13 congeners of PBDEs). The interactions induced by NFRs complicated the original sex hormone disruption led by PCBs and PBDEs. The disrupting effects and interactions induced by NFRs decreased female FSH levels in the exposed group. Comprehensive evaluation is needed to provide the evidence base for judging the health risks arising from the increased usage of NFRs.
机译：尽管多氯联苯（PCB）和多溴联苯醚（PBDEs）对性激素的破坏作用已广为人知，但与新型阻燃剂（NFR）相关的类似作用尚未得到很好的研究。这项研究旨在通过在华南电子废物拆解和控制地区进行的生态研究，探讨NFRs的性激素破坏及其与PCBs和PBDEs的相互作用。从当地成年居民那里收集问卷和血液样本。广义加性模型和线性回归分析的结果表明，几种NFR对PBDE同系物对雌性卵泡刺激素（FSH）和雄性睾丸激素显示出相似的破坏作用。从弯曲的形状和统计学意义来看，Sigma NFR（8种NFR的总和）显示出比Sigma PBDE（13种PBDEs的总和）对雄性睾丸激素和雌性FSH的破坏作用更强。 NFR诱导的相互作用使PCBs和PBDEs导致的原始性激素破坏复杂化。 NFRs引起的破坏作用和相互作用降低了暴露组中女性FSH的水平。需要进行综合评估，以提供依据，以判断因使用NFR增加而引起的健康风险。

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