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首页> 外文期刊>Environmental Science & Technology >'Cocktail' of Xenobiotics at Human Relevant Levels Reshapes the Gut Bacterial Metabolome in a Species-Specific Manner
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'Cocktail' of Xenobiotics at Human Relevant Levels Reshapes the Gut Bacterial Metabolome in a Species-Specific Manner

机译：异种生物在人体相关水平上的“鸡尾酒”以一种特定于物种的方式重塑肠道细菌代谢组。

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摘要

The human gut microbiome experiences long-term exposure to numerous organic contaminants (e.g., xenobiotics) in the digestive tract, and the possible consequences have rarely been characterized. To date, very few studies have investigated the metabolic variation from different species of gut bacteria in response to xenobiotic mixtures. In this study, we applied liquid chromatography mass spectrometry-based global metabolomics, coupled with targeted metabolomics, to characterize the model gut bacterial responses toward the xenobiotic mixture, covering diverse classes of compounds at human relevant concentrations. The xenobiotic "cocktail" will not likely affect the growth or morphological properties of model bacteria at human relevant concentrations. However, the metabolic results were distinct between four model bacteria and dose levels, showing species-specific and dose-dependent responsive patterns among different commensal gut bacteria. The key metabolites responsive to xenobiotic exposure are mainly involved in amino acid metabolism and central carbon metabolism, including sulfur-containing amino acids, aromatic amino acids, amino sugars, neurotransmitters, and energy-related metabolic pathways. Many of those metabolites also play an important role in the host's health. In summary, our results show that the gut microbiome can be significantly perturbed by exposure to xenobiotic mixtures at human relevant levels, providing key information on susceptibilities of individuals with diverse gut microbial structures.
机译：人体肠道微生物组会长期暴露于消化道中的许多有机污染物（例如异种生物）中，其可能的后果很少得到描述。迄今为止，很少有研究调查异种混合物对不同肠道细菌物种代谢的影响。在这项研究中，我们应用了基于液相色谱质谱的全球代谢组学和靶向代谢组学，来表征模型肠道细菌对异种混合物的反应，涵盖人类相关浓度下的各种化合物。在人类相关浓度下，异种“鸡尾酒”将不会影响模型细菌的生长或形态特性。然而，四种模式细菌和剂量水平之间的代谢结果是不同的，显示出不同共肠细菌之间的物种特异性和剂量依赖性响应模式。对异源生物暴露有反应的关键代谢物主要参与氨基酸代谢和中心碳代谢，包括含硫氨基酸，芳香族氨基酸，氨基糖，神经递质和与能量有关的代谢途径。这些代谢物中的许多也对宿主的健康起着重要作用。总而言之，我们的结果表明，肠道微生物组可以通过与人类相关水平的异种混合物接触而受到显着扰动，从而提供了具有多种肠道微生物结构的个体的药敏性的关键信息。

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  • 来源
    《Environmental Science & Technology》 |2018年第19期|11402-11410|共9页
  • 作者

    Zhang Yingdan; Keerthisinghe Tharushi Prabha; Han Yuan; Liu Min; Wanjaya Elvy Riani; Fang Mingliang;

  • 作者单位

    Nanyang Technol Univ, Sch Civil & Environm Engn, Singapore 639798, Singapore;

    Nanyang Technol Univ, Sch Civil & Environm Engn, Singapore 639798, Singapore;

    Nanyang Technol Univ, Nanyang Environm & Water Res Inst, Analyt Cluster, Singapore 637141, Singapore;

    Nanyang Technol Univ, Sch Civil & Environm Engn, Singapore 639798, Singapore;

    Nanyang Technol Univ, Nanyang Environm & Water Res Inst, Analyt Cluster, Singapore 637141, Singapore;

    Nanyang Technol Univ, Sch Civil & Environm Engn, Singapore 639798, Singapore;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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