...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption
【24h】

Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption

机译：纳米塑料摄入可通过多异源生物抗性（MXR）破坏增强单核轮虫Brachionus koreanus中持久性有机污染物（POPs）的毒性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Among the various materials found inside microplastic pollution, nanosized microplastics are of particular concern due to difficulties in quantification and detection; moreover, they are predicted to be abundant in aquatic environments with stronger toxicity than microsized microplastics. Here, we demonstrated a stronger accumulation of nanosized microbeads in the marine rotifer Brachionus koreanus compared to microsized ones, which was associated with oxidative stress-induced damages on lipid membranes. In addition, multixenobiotic resistance conferred by P-glycoproteins and multidrug resistance proteins, as a first line of membrane defense, was inhibited by nanoplastic pre-exposure, leading to enhanced toxicity of 2,2',4,4'-tetrabromodiphenyl ether and triclosan in B. koreanus. Our study provides a molecular mechanistic insight into the toxicity of nanosized microplastics toward aquatic invertebrates and further implies the significance of synergetic effects of microplastics with other environmental persistent organic pollutants.
机译：在塑料微粒污染内部发现的各种材料中，由于难以量化和检测，因此特别关注纳米塑料微粒。此外，据预测它们在水生环境中含量丰富，毒性比微米级微塑料强。在这里，我们证明了与小尺寸轮虫相比，海洋轮虫Brachionus koreanus中纳米尺寸的微珠积累更强，这与氧化应激诱导的脂质膜损伤有关。此外，纳米糖预暴露抑制了P-糖蛋白和多药抗性蛋白赋予的多异生素抗性，这是膜防御的第一道防线，导致2,2'，4,4'-四溴二苯醚和三氯生的毒性增强在朝鲜。我们的研究提供了分子力学的洞察力，纳米塑料对水生无脊椎动物的毒性，并进一步暗示了塑料与其他环境持久性有机污染物协同作用的重要性。

著录项

  • 来源
    《Environmental Science & Technology》 |2018年第19期|11411-11418|共8页
  • 作者

    Jeong Chang-Bum; Kang Hye-Min; Lee Young Hwan; Kim Min-Sub; Lee Jin-Sol; Seo Jung Soo; Wang Minghua; Lee Jae-Seong;

  • 作者单位

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

    Natl Inst Fisheries Sci, Pathol Div, Busan 46083, South Korea;

    Xiamen Univ, Coll Environm & Ecol, Minist Educ Coastal & Wetland Ecosyst, Key Lab, Xiamen 361102, Peoples R China;

    Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号