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首页> 外文期刊>Environmental Science & Technology >Study of the Persistence of the Phytotoxicity Induced by Graphene Oxide Quantum Dots and of the Specific Molecular Mechanisms by Integrating Omics and Regular Analyses
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Study of the Persistence of the Phytotoxicity Induced by Graphene Oxide Quantum Dots and of the Specific Molecular Mechanisms by Integrating Omics and Regular Analyses

机译：通过组学和常规分析相结合的方法研究氧化石墨烯量子点引起的植物毒性的持久性及其分子机制

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摘要

Although increasing attention has been paid to the nanotoxicity of graphene oxide quantum dots (GOQDs) due to their broad range of applications, the persistence and recoverability associated with GOQDs had been widely ignored. Interestingly, stress-response hormesis for algal growth was observed for Chlorella vulgaris as a single-celled model organism. Few physiological parameters, such as algal density, plasmolysis, and levels of reactive oxygen species, exhibited facile recovery. In contrast, the effects on chlorophyll a levels, permeability, and starch grain accumulation exhibited persistent toxicity. In the exposure stage, the downregulation of genes related to unsaturated fatty acid biosynthesis, carotenoid biosynthesis, phenylpropanoid biosynthesis, and binding contributed to toxic effects on photosynthesis. In the recovery stage, downregulation of genes related to the cis-Golgi network, photosystem I, photosynthetic membrane, and thylakoid was linked to the persistence of toxic effects on photosynthesis. The upregulated galactose metabolism and downregulated aminoacyl-tRNA biosynthesis also indicated toxicity persistence in the recovery stage. The downregulation and upregulation of phenylalanine metabolism in the exposure and recovery stages, respectively, reflected the tolerance of the algae to GOQDs. The present study highlights the importance of studying nanotoxicity by elucidation of stress and recovery patterns with metabolomics and transcriptomics.
机译：尽管由于它们的广泛应用，人们已经越来越关注氧化石墨烯量子点（GOQD）的纳米毒性，但是与GOQD相关的持久性和可回收性却被广泛忽略。有趣的是，对于作为单细胞模型生物的小球藻，观察到了藻类生长的应激反应激素。很少的生理参数，例如藻类密度，溶酶作用和活性氧的含量，显示出容易恢复。相反，对叶绿素a水平，通透性和淀粉粒积累的影响表现出持续的毒性。在暴露阶段，与不饱和脂肪酸生物合成，类胡萝卜素生物合成，苯基丙烷生物合成和结合相关的基因的下调导致了对光合作用的毒性作用。在恢复阶段，与顺式-高尔基网络，光系统I，光合膜和类囊体相关的基因的下调与对光合作用的持久毒性有关。半乳糖代谢的上调和氨基酰基-tRNA的生物合成下调也表明恢复阶段的毒性持续存在。在暴露和恢复阶段苯丙氨酸代谢的下调和上调分别反映了藻类对GOQD的耐受性。本研究强调了通过代谢组学和转录组学阐明应激和恢复模式来研究纳米毒性的重要性。

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  • 来源
    《Environmental Science & Technology》 |2019年第7期|3791-3801|共11页
  • 作者

    Kang Weilu; Li Xiaokang; Sun Anqi; Yu Fubo; Hu Xiangang;

  • 作者单位

    Nankai Univ, Tianjin Key Lab Environm Remediat & Pollut Contro, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin 300350, Peoples R China;

    Nankai Univ, Tianjin Key Lab Environm Remediat & Pollut Contro, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin 300350, Peoples R China;

    Nankai Univ, Tianjin Key Lab Environm Remediat & Pollut Contro, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin 300350, Peoples R China;

    Nankai Univ, Tianjin Key Lab Environm Remediat & Pollut Contro, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin 300350, Peoples R China;

    Nankai Univ, Tianjin Key Lab Environm Remediat & Pollut Contro, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin 300350, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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