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首页> 外文期刊>Environmental Science & Technology >Formation, Identification, and Occurrence of New Bromo- and Mixed Halo-Tyrosyl Dipeptides in Chloraminated Water
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Formation, Identification, and Occurrence of New Bromo- and Mixed Halo-Tyrosyl Dipeptides in Chloraminated Water

机译：氯化水中新的溴和混合卤代酪氨酰二肽的形成，鉴定和发生

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摘要

Dipeptides are widely present in surface water and serve as precursors to form disinfection byproducts (DBPs) during disinfection (e.g., chloramination). Bromide (Br-) and iodide (I-) are common in many source waters, enhancing Br- and I-DBP formation. Recently Cl-, I-, and Cl-I-dipeptides were identified after chloramination of tyrosyl dipeptides in the presence of I- and were detected in authentic disinfected drinking water samples. However, the formation and occurrence of Br- and mixed halogen (Cl, Br, and/or I)-dipeptides in disinfected water have not been studied. Here we investigated the formation of halogenated dipeptides from three aromatic dipeptides, phenylalanylglycine (Phe-Gly), tyrosylalanine (Tyr-Ala), and tyrosylglycine (Tyr-Gly), under chloramination in the presence of Br and I- at environmentally relevant levels ([Br-] and [I-], 0 and 0 mu g L-1, 6 and 30 mu g L-1, 30 and 30 mu g L-1, 150 and 30 mu g L-1, 300 and 30 mu g L-1, and 900 and 30 mu g L-1, respectively). For the first time, N-Br- and N,N-di-Br- as well as N-Br-N-Cl- and N-Br-3-I-tyrosyl dipeptides were identified using infusion electrospray quadrupole time-of-flight mass spectrometry. Tyrosyl dipeptides produced N-Cl-, 3-I-/3,5-di-I-, and N-Cl-3-I-tyrosyl dipeptides, while Phe-Gly formed only N-Cl-/N,N-di-Cl-Phe-Gly. To determine halogenated dipeptides in authentic water samples, we developed a new method of solid phase extraction and high-performance liquid chromatography with quadrupole ion trap mass spectrometry using reaction monitoring. 3,5-Di-I-Tyr-Ala and N-Br-Tyr-Ala were detected in treated water but not in the corresponding raw water, warranting further investigation into the occurrence of halogenated peptides in other drinking water systems.
机译：二肽广泛存在于地表水中，并作为在消毒（例如氯化）过程中形成消毒副产物（DBP）的前体。溴化物（Br-）和碘化物（I-）在许多水源水中都很常见，从而增加了Br-和I-DBP的形成。最近，在I-存在下酪氨酰二肽氯化后，鉴定了Cl-，I-和Cl-I-二肽，并在经过消毒的纯净饮用水样品中进行了检测。但是，尚未研究在消毒水中溴和混合卤素（Cl，Br和/或I）二肽的形成和存在。在这里，我们研究了在存在环境相关水平的Br和I-存在下，在氯化作用下，由三种芳香族二肽（苯丙氨酰甘氨酸（Phe-Gly），酪氨酰丙氨酸（Tyr-Ala）和酪氨酰甘氨酸（Tyr-Gly））形成的卤化二肽（ [Br-]和[I-]，0和0微克L-1、6和30微克L-1、30和30微克L-1、150和30微克L-1、300和30微克g L-1，分别为900和30μgL-1）。首次使用注入电喷雾四极杆时间质谱仪鉴定了N-Br-和N，N-di-Br-以及N-Br-N-Cl-和N-Br-3-I-酪氨酰二肽飞行质谱。酪氨酰二肽产生N-Cl-，3-I- / 3,5-二-I-和N-Cl-3-I-酪氨酰二肽，而Phe-Gly仅形成N-Cl- / N，N-di -Cl-Phe-Gly。为了测定真实水样中的卤代二肽，我们开发了一种新的固相萃取和高效液相色谱法，并采用四极杆离子阱质谱进行反应监测。在处理过的水中检测到3,5-Di-I-Tyr-Ala和N-Br-Tyr-Ala，但未在相应的原水中检测到，因此有必要进一步研究其他饮用水系统中卤代肽的存在。

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  • 来源
    《Environmental Science & Technology》 |2019年第7期|3672-3680|共9页
  • 作者

    Huang Guang; Blackstock Lindsay K. Jmaiff; Jiang Ping; Liu Zhongshan; Lu Xiufen; Li Xing-Fang;

  • 作者单位

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

    Univ Alberta, Fac Med & Dent, Div Analyt & Environm Toxicol, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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