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首页> 外文期刊>Environmental Science & Technology >Antibiotic Resistome Alteration by Different Disinfection Strategies in a Full-Scale Drinking Water Treatment Plant Deciphered by Metagenomic Assembly
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Antibiotic Resistome Alteration by Different Disinfection Strategies in a Full-Scale Drinking Water Treatment Plant Deciphered by Metagenomic Assembly

机译：元基因组大会破译的大型饮用水处理厂中不同消毒策略对抗生素抵抗力的影响

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摘要

Disinfection regimes are considered the most solid strategy to reduce microbial risks in drinking water, but their roles in shaping the antibiotic resistome are poorly understood. This study revealed the alteration of antibiotic resistance genes (ARGs) profiles, their co-occurrence with mobile genetic elements (MGEs), and potential hosts during drinking water disinfection based on metagenomic assembly. We found the ozone/chlorine (O-3/Cl-2) coupled disinfection significantly increased the relative abundance of ARGs and MGE-carrying antibiotic resistance contigs (ARCs) through the enrichment of ARGs within the resistance-nodulation-cell-division and ATP-binding cassette antibiotic efflux families that are primarily carried by Pseudomonas, Acinetobacter, Mycobacterium, and Methylocystis, whereas the antimicrobial resin/chlorine coupled disinfection posed unremarkable changes to the ARG and MGE abundances. Moreover, the co-occurrence patterns of antibiotic efflux and beta-lactam ARGs and MGEs were widely identified, and ARCs carrying the recR and mexH genes were detected in all the samples, with the highest abundance of 2.25 X 10(-2) copies per cell after O-3/Cl-2 disinfection. Sequence-independent binning analysis successfully retrieved two draft ARG-carrying genomes of Acidovorax sp. MR-S7 and Hydrogenophaga sp. IBVHS2 further revealing the host-ARG relationship during O-3/Cl-2 disinfection. Overall, this study provides novel insights into the antibiotic resistome alteration during drinking water disinfection.
机译：消毒制度被认为是降低饮用水中微生物风险的最可靠的策略，但是人们对消毒制度在塑造抗生素抗药性中的作用知之甚少。这项研究揭示了在基于宏基因组学的饮用水消毒过程中，抗生素抗性基因（ARG）谱的变化，它们与移动遗传元件（MGEs）的共存以及潜在宿主的变化。我们发现臭氧/氯（O-3 / Cl-2）耦合消毒通过在耐药性结节细胞分裂和ATP中富集ARGs显着增加了ARGs和携带MGE的抗生素耐药菌群（ARCs）的相对丰度。 -结合盒式抗生素外排家族，主要由假单胞菌，不动杆菌，分枝杆菌和甲基囊藻携带，而抗菌树脂/氯偶联消毒对ARG和MGE的丰度没有显着变化。此外，广泛识别出抗生素外排，β-内酰胺ARG和MGE的共现模式，并且在所有样品中均检测到带有recR和mexH基因的ARC，其最高丰度为2.25 X 10（-2）个拷贝O-3 / Cl-2消毒后的细胞。独立于序列的装箱分析成功地检索了两个携带Acordovorax sp的ARG草案基因组。 MR-S7和Hydrogenophaga sp。 IBVHS2进一步揭示了O-3 / Cl-2消毒过程中的宿主-ARG关系。总的来说，这项研究为饮用水消毒过程中抗生素抵抗力的改变提供了新的见解。

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  • 来源
    《Environmental Science & Technology》 |2019年第4期|2141-2150|共10页
  • 作者

    Zhang Huaicheng; Chang Fangyu; Shi Peng; Ye Lin; Zhou Qing; Pan Yang; Li Aimin;

  • 作者单位

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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