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首页> 外文期刊>Environmental Science & Technology >Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna
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Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna

机译：铝和铟的混合物在水蚤中诱导的加性表型和毒物基因组反应更多

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摘要

Aquatic systems are contaminated by many metals but their effects as mixtures on organisms are not well understood. Here, we assessed effects of aluminum with fairly well-known modes of actions and indium, an understudied emerging contaminant from electronics, followed by studying equi-effective mixtures thereof. We report acute and adverse phenotypic effects in Daphnia magna adults and global transcriptomic effects employing RNA sequencing in neonates. The mixture induced more than additive activity in mortality and in physiological effects, including growth and reproduction. Similarly, transcriptomic effects were more than additive, as indicated by a markedly higher number of 463 differentially expressed transcripts in the mixture and by distinct classes of genes assigned to several biological functions, including metabolic processes, suggesting depleted energy reserves, which may be responsible for the observed impaired reproduction and growth. A gene set enrichment analysis (GSEA) of a priori known response pathways for aluminum confirmed activation of distinct molecular pathways by indium. Our study is highlighting more than additive effects at the transcriptional and physiological level and is providing a state-of-the art approach to mixture analysis, which is important for risk assessment of these metals and metal mixtures.
机译：水生系统被许多金属污染，但它们作为混合物对生物的影响尚不十分清楚。在这里，我们以众所周知的作用方式评估了铝和铟（一种未被充分研究的电子学污染物）的作用，然后研究了其等效混合物。我们报告在大型蚤中成年人的急性和不良表型的影响，并在新生儿中采用RNA测序的全球转录效应。该混合物在死亡率和生理影响（包括生长和繁殖）中的诱导作用超过了加和活性。同样，转录组的作用大于累加，如混合物中463个差异表达的转录物的数量明显增加，以及分配给几种生物功能（包括代谢过程）的基因类别不同，表明能量储备不足，这可能是造成这种情况的原因。观察到的繁殖和生长受损。铝的先验已知反应途径的基因集富集分析（GSEA）证实了铟激活了独特的分子途径。我们的研究不仅在转录和生理水平上突出了累加效应，而且还提供了一种最新的混合物分析方法，这对于这些金属和金属混合物的风险评估非常重要。

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  • 来源
    《Environmental Science & Technology》 |2019年第3期|1639-1649|共11页
  • 作者

    Brun Nadja R.; Fields Peter D.; Horsfield Samuel; Mirbahai Leda; Ebert Dieter; Colbourne John K.; Fent Karl;

  • 作者单位

    Univ Appl Sci & Arts Northwestern Switzerland, Sch Life Sci, Langackerstr 30, CH-4132 Muttenz, Switzerland|Swiss Fed Inst Technol, Inst Biogeochem & Pollutant Dynam, Univ Str 16, CH-8092 Zurich, Switzerland|Woods Hole Oceanog Inst, Biol Dept, Woods Hole, MA 02543 USA;

    Univ Basel, Zool Inst, Vesalgasse 1, CH-4051 Basel, Switzerland;

    Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England;

    Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England;

    Univ Basel, Zool Inst, Vesalgasse 1, CH-4051 Basel, Switzerland;

    Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England;

    Univ Appl Sci & Arts Northwestern Switzerland, Sch Life Sci, Langackerstr 30, CH-4132 Muttenz, Switzerland|Swiss Fed Inst Technol, Inst Biogeochem & Pollutant Dynam, Univ Str 16, CH-8092 Zurich, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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