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首页> 外文期刊>Environmental Science & Technology >Perfluoroalkyl Acids (PFAAs) in Children's Serum and Contribution from PFAA-Contaminated Drinking Water
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Perfluoroalkyl Acids (PFAAs) in Children's Serum and Contribution from PFAA-Contaminated Drinking Water

机译：儿童血清中的全氟烷基酸（PFAAs）及其受PFAA污染的饮用水的贡献

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摘要

We investigated associations between serum perfluoroalkyl acid (PFAA) concentrations in children aged 4, 8, and 12 years (sampled in 2008-2015; n = 57, 55, and 119, respectively) and exposure via placental transfer, breastfeeding, and ingestion of PFAA-contaminated drinking water. Sampling took place in Uppsala County, Sweden, where the drinking water has been historically contaminated with perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluoroheptanoate (PFHpA), and perfluorooctanoate (PFOA). PFOS showed the highest median concentrations in serum (3.8-5.3 ng g(-1) serum), followed by PFHxS (1.6-5.0 ng g(-1) serum), PFOA (2.0-2.5 ng g(-1) serum), and perfluorononanoate (PFNA) (0.59-0.69 ng g(-1) serum) in children. Including all children, serum PFOA, PFHxS, and PFOS concentrations (adjusted mean), respectively, per unit (ng g(-1) serum) of increase in the maternal serum level (at delivery), the associations being strongest for 4 year-old children. PFHxS and PFOS significantly increased 3.9 and 3.8%, respectively, per month of nursing, with the highest increase for 4 year-olds. PFOA, PFBS, PFHxS, and PFOS increased 1.2, 207, 7.4, and 0.93%, respectively, per month of cumulative drinking water exposure. Early life exposure to PFOA, PFHxS, and PFOS is an important determinant of serum concentrations in children, with the strongest influence on younger ages. Drinking water with low to moderate PFBS, PFHxS, PFOS, and PFOA contamination is an important source of exposure for children with background exposure from other sources.
机译：我们调查了4岁，8岁和12岁儿童的全氟烷基酸（PFAA）浓度（分别于2008-2015年进行抽样;分别为n = 57、55和119）与通过胎盘转移，母乳喂养和摄入母体的暴露之间的关联。受PFAA污染的饮用水。采样在瑞典的乌普萨拉县进行，该饮用水在历史上曾被全氟丁烷磺酸盐（PFBS），全氟己烷磺酸盐（PFHxS），全氟辛烷磺酸盐（PFOS），全氟庚酸酯（PFHpA）和全氟辛酸（PFOA）污染。 PFOS显示最高的血清中值浓度（3.8-5.3 ng g（-1）血清），其次是PFHxS（1.6-5.0 ng g（-1）血清），PFOA（2.0-2.5 ng g（-1）血清） ，以及儿童全氟壬酸（PFNA）（血清0.59-0.69 ng g（-1））。包括所有儿童在内，母体血清水平（分娩时）每单位（ng g（-1）血清）升高的血清PFOA，PFHxS和PFOS浓度（调整后平均值）分别为4年，大孩子。 PFHxS和PFOS分别每月显着增加3.9和3.8％，其中4岁儿童的增幅最高。 PFOA，PFBS，PFHxS和PFOS每月累积饮用水暴露量分别增加1.2％，207％，7.4％和0.93％。尽早接触PFOA，PFHxS和PFOS是儿童血清浓度的重要决定因素，对幼儿的影响最大。 PFBS，PFHxS，PFOS和PFOA污染程度低至中度的饮用水是其他背景暴露儿童的重要暴露来源。

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  • 来源
    《Environmental Science & Technology》 |2019年第19期|11447-11457|共11页
  • 作者

    Gyllenhammar Irina; Benskin Jonathan P.; Sandblom Oskar; Berger Urs; Ahrens Lutz; Lignell Sanna; Wiberg Karin; Glynn Anders;

  • 作者单位

    Natl Food Agcy Dept Risk & Benefit Assessment POB 622 SE-75126 Uppsala Sweden;

    Stockholm Univ Dept Environm Sci & Analyt Chem ACES SE-10691 Stockholm Sweden;

    UFZ Helmholtz Ctr Environm Res Dept Analyt Chem Permoserstr 15 DE-04318 Leipzig Germany;

    Swedish Univ Agr Sci SLU Dept Aquat Sci & Assessment Box 7050 Uppsala Sweden;

    Swedish Univ Agr Sci SLU Dept Biomed Sci & Vet Publ Hlth Box 7028 SE-75007 Uppsala Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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