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首页> 外文期刊>Environmental Science & Technology >Lung Antioxidant Depletion: A Predictive Indicator of Cellular Stress Induced by Ambient Fine Particles
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Lung Antioxidant Depletion: A Predictive Indicator of Cellular Stress Induced by Ambient Fine Particles

机译：肺抗氧化剂耗竭：环境微粒引起的细胞应激的预测指标。

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摘要

Regulations on ambient particulate matter (PM) are becoming more stringent because of adverse health effects arising from PM exposure. PM-induced oxidant production is a key mechanism behind the observed health effects and is heavily dependent on PM composition. Measurement of the intrinsic oxidative potential (OP) of PM could provide an integrated indicator of PM bioreactivity and could serve as a better metric of PM hazard exposure than PM mass concentration. The OP of two chemically contrasted PM_(2.5) samples was compared through four acellular assays, and OP predictive capability was evaluated in different cellular assays on two in vitro lung cell models. PM_(2.5) collected in Paris at a site close to the traffic exhibited a systematically higher OP in all assays compared to PM_(2.5) enriched in particles from domestic wood burning. Similar results were obtained for oxidative stress, expression of antioxidant enzymes, and pro-inflammatory chemokine in human bronchial epithelial and endothelial cells. The strongest correlations between OP assays and cellular responses were observed with the antioxidant (ascorbic acid and glutathione) depletion (OP~(AO)) assay. Multivariate regression analysis from OP daily measurements suggested that OP~(AO) was strongly correlated with polycyclic aromatic hydrocarbons at the traffic site while it was correlated with potassium for the domestic wood burning sample.
机译：由于暴露于PM会对健康造成不利影响，因此有关环境颗粒物（PM）的法规变得更加严格。 PM诱导的氧化剂产生是观察到的健康影响背后的关键机制，并且在很大程度上取决于PM的组成。 PM的固有氧化电位（OP）的测量可以提供PM生物反应性的综合指标，并且可以比PM质量浓度更好地衡量PM危害暴露程度。通过四个脱细胞分析比较了两个化学对比的PM_（2.5）样品的OP，并在两个体外肺细胞模型的不同细胞分析中评估了OP的预测能力。与从家用木材燃烧中富集颗粒物的PM_（2.5）相比，在巴黎所有靠近检测点的地点收集到的PM_（2.5）在所有测定中均表现出系统地较高的OP。对于人支气管上皮和内皮细胞中的氧化应激，抗氧化酶的表达和促炎性趋化因子，也获得了相似的结果。用抗氧化剂（抗坏血酸和谷胱甘肽）耗竭（OP〜（AO））分析可观察到OP分析与细胞反应之间最强的相关性。 OP日测量的多元回归分析表明，OP〜（AO）与交通现场的多环芳烃有很强的相关性，而家用木材燃烧样品中的OP〜（AO）与钾有很强的相关性。

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  • 来源
    《Environmental Science & Technology》 |2020年第4期|2360-2369|共10页
  • 作者

    Belinda Crobeddu; Isabelle Baudrimont; Juliette Deweirdt; Jean Sciare; Anne Badel; Anne-Claude Camproux; Linh Chi Bui; Armelie Baeza-Squiban;

  • 作者单位

    Université de Paris BFA UMR 8251 CNRS F-75013 Paris France;

    Université de Bordeaux Centre de Recherche Cardio-Thoracique de Bordeaux U1045 F-33604 Pessac France;

    Laboratoire des Sciences du Climat et de l'Environnement CEA-CNRS-UVSQ F-91190 Gif-sur-Yvette France Energy Environment and Water Research Center The Cyprus Institute 2121 Aglantzia Cyprus;

    Université de Paris BFA UMR 8251 CNRS ERL 1133 Inserm F-75013 Paris France;

    Université de Paris BFA UMR 8251 CNRS F-75013 Paris France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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