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首页> 外文期刊>Environmental Science & Technology >Visualized Metabolic Disorder and Its Chemical Inducer in Wild Crucian Carp from Taihu Lake, China
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Visualized Metabolic Disorder and Its Chemical Inducer in Wild Crucian Carp from Taihu Lake, China

机译：太湖野生Cru鱼的可视化代谢紊乱及其化学诱导物

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摘要

A variety of anthropogenic chemicals can disrupt the equilibrium of intrinsic biological metabolites in organisms, leading to metabolic disorders and an increased risk of metabolic syndromes. However, exposure to pollutants that induce metabolic disorders in wildlife as a cause of adverse effects is unknown. In this study, approximately 3108 compounds, including 11 groups of metabolites and 388 pollutants, were simultaneously identified in the blood of wild crucian carp (Carassius auratus) captured in three bays of Taihu Lake, China. A visualized network linking thousands of co-regulated metabolites was automatically produced for the screened signals. This comprehensive view of the differences in blood metabolite profiles in carp from the north and south bays showed that triglycerides (TGs) were the intrinsic molecules most affected by differing environmental pollution in each bay. The regional differences in metabolite profiles were linked to exposure to screened perfluorinated compounds that displayed corresponding regional differences in concentrations and effects on TGs in in vivo exposure tests. Perfluoroundecanoic acid (PFUnDA) was the key pollutant responsible for the variation in blood TGs in wild crucian carp, and exposure to PFUnDA resulted in extremely high biological activity on lipid deposition in the liver tissues of crucian carp at environmental levels.
机译：多种人为化学物质可以破坏生物体内固有的生物代谢物的平衡，导致代谢紊乱和代谢综合征的风险增加。但是，尚不清楚暴露于会引起野生动植物代谢紊乱的有害影响的污染物。在这项研究中，在中国太湖三个海湾捕获的野生cru鱼血液中同时鉴定出约3108种化合物，包括11种代谢物和388种污染物。连接筛选的信号的成千上万的代谢物的可视化网络自动产生。对北部和南部海湾鲤鱼血液代谢产物谱差异的全面了解表明，甘油三酸酯（TGs）是每个海湾中受不同环境污染影响最大的内在分子。代谢物谱的区域差异与暴露于筛选的全氟化合物的暴露有关，全氟化合物在体内暴露测试中显示出相应的浓度差异和对TG的影响。全氟十一酸（PFUnDA）是造成wild鱼血液中TGs变化的主要污染物，在环境水平下，PFUnDA的暴露对on鱼肝组织中脂质沉积的生物学活性极高。

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  • 来源
    《Environmental Science & Technology》 |2020年第6期|3343-3352|共10页
  • 作者

    Shixiong Gao; Hang Liu; Hong Chang; Zhaobin Zhang; Jianying Hu; Shu Tao; Yi Wan;

  • 作者单位

    Laboratory for Earth Surface Processes College of Urban and Environmental Sciences Peking University Beijing 100871 China;

    Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Sciences & Engineering Beijing Forestry University Beijing 100083 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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