...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China
【24h】

Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China

机译：产前暴露于有机磷酸酯阻燃剂和低出生体重的风险：中国的一项嵌套病例对照研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Organophosphate flame retardants (OPFRs), used as flame retardants and plasticizers, have been suggested to impair fetal growth and development in toxicological studies, but epidemiological data are extremely limited. This study was designed to explore whether prenatal exposure to OPFRs was associated with an increased risk of low birth weight (LBW) using a nested case-control design based on the ongoing prospective birth cohort in Wuhan, China. A total of 113 cases and 226 matched controls recruited from this cohort project in 2014-2016 were included. OPFR metabolite concentrations in maternal urine samples collected in the third trimester were determined, and birth outcomes were extracted from medical records. Compared with the lowest tertile of diphenyl phosphate (DPHP) concentrations, pregnant women with the highest tertile of DPHP had a 4.62-fold (95% confidence interval (CI): 1.72, 12.40) significantly increased risk for giving birth to LBW infants, with a significant dose—response relationship (p-trend < 0.01). After stratification by newborn sex, the significant positive association of DPHP levels with LBW risk was merely observed among female newborns. Our results suggest a positive association between maternal urinary DPHP concentrations and LBW risk for the first time, and the effect appears be sex-specific.
机译：在毒理学研究中已建议用作阻燃剂和增塑剂的有机磷酸酯阻燃剂（OPFRs）损害胎儿的生长发育，但流行病学数据极为有限。本研究旨在基于中国武汉市正在进行的预期出生队列的嵌套病例对照设计，探讨产前暴露于OPFRs是否与增加低出生体重（LBW）的风险有关。 2014-2016年从该队列项目招募的总共113例病例和226个匹配的对照。确定了妊娠中期孕妇尿液样本中OPFR代谢物的浓度，并从医疗记录中提取了出生结局。与磷酸二苯酯（DPHP）的最低三分位数相比，具有最高DPHP三分位数的孕妇的生育率是婴儿期的4.62倍（95％置信区间（CI）：1.72、12.40），显着增加了显着的剂量反应关系（p趋势<0.01）。在按新生儿性别分层后，仅在女性新生儿中观察到DPHP水平与LBW风险显着正相关。我们的结果首次表明，孕妇尿液DPHP浓度与LBW风险呈正相关，且这种影响似乎是性别特异性的。

著录项

  • 来源
    《Environmental Science & Technology》 |2020年第6期|3375-3385|共11页
  • 作者

    Dan Luo; Wenyu Liu; Yun Tao; Limei Wang; Meng Yu; Liqin Hu; Aifen Zhou; Adrian Covad; Wei Xia; Yuanyuan Li; Shunqing Xu; Surong Mei;

  • 作者单位

    Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key laboratory of Environment Health (Incubation) School of Public Health Tongji Medical College Huazhong University oj Science and Technology Wuhan 430030 China Guangdong Key Laboratory of Environmental Pollution and Health School of Environment Jinan University Guangzhou 511443 China;

    Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key laboratory of Environment Health (Incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Division of Birth Cohort Study Guangzhou Women and Children's Medical Center and Department of Obstetrics and Gynecology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou 510632 China;

    Key laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key Laboratory of Environment Health (Incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

    Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key Laboratory of Environment Health (Incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

    Wuhan Maternal and Child Healthcare Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

    Toxicological Center University of Antwerp 2610 Wilrijk Belgium;

    Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key laboratory of Environment Health (Incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号