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首页> 外文期刊>Environmental Science & Technology >Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish
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Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

机译：甲卓过氧化酶和脱碘酶抑制对斑马鱼前泳膀胱通胀的影响

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摘要

A set of adverse outcome pathways (AOPs) linking inhibition of thyroperoxidase and deiodinase to impaired swim bladder inflation in fish has recently been developed. These AOPs help to establish links between these thyroid hormone (TH) disrupting molecular events and adverse outcomes relevant to aquatic ecological risk assessment. Until now, very little data on the effects of TH disruption on inflation of the anterior chamber (AC) of the swim bladder were available. The present study used zebrafish exposure experiments with three model compounds with distinct thyroperoxidase and deiodinase inhibition potencies (methimazole, iopanoic acid, and propylthiouracil) to evaluate this linkage. Exposure to all three chemicals decreased whole body triiodothyronine (T3) concentrations, either through inhibition of thyroxine (T4) synthesis or through inhibition of Dio mediated conversion of T4 to T3. A quantitative relationship between reduced T3 and reduced AC inflation was established, a critical key event relationship linking impaired swim bladder inflation to TH disruption. Reduced inflation of the AC was directly linked to reductions in swimming distance compared to controls as well as to chemical-exposed fish whose ACs inflated. Together the data provide compelling support for AOPs linking TH disruption to impaired AC inflation in fish.
机译：最近开发了一系列不良结果途径（AOPs）将甲羟氢氧化酶和脱碘酶抑制抑制鱼类在鱼类中的游泳膀胱通胀受损。这些AOP有助于建立这些甲状腺激素（TH）之间破坏分子事件和与水生态风险评估相关的不利结果之间的联系。到目前为止，可以获得关于游泳膀胱前房（AC）的膨胀对膨胀的影响的数据很少。本研究使用了三种模型化合物的斑马鱼暴露实验，其中三种模型化合物具有不同的甲吡嗪酶和脱碘酶抑制效能（甲基唑，碘甲酸和丙基硫嘧啶）来评估这种联系。暴露于所有三种化学物质，通过抑制甲状腺素（T4）合成或通过抑制DIO介导的T4至T3的DIO介导的转化率下降到全身三碘噻吩（T3）浓度下降。建立了减少T3和减少交流通货膨胀之间的定量关系，这是一种关键的关键事件关系，这些关键的关键事件关系将损害的游泳膀胱通胀与破坏中断。减少AC的膨胀直接与游泳距离的降低相比，与对照以及ACS充气的化学曝光的鱼类相比。这些数据在一起为ABOPS链接令人兴奋的支持，这些支持与鱼类中的AC通胀受损。

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  • 来源
    《Environmental Science & Technology》 |2020年第10期|6213-6223|共11页
  • 作者

    Evelyn Stinckens; Lucia Vergauwen; Brett R. Blackwell; Gerald T. Ankley; Daniel L. Villeneuve; Dries Knapen;

  • 作者单位

    Zebrafishlab Veterinary Physiology and Biochemistry Department of Veterinary Sciences University of Antwerp 2610 Wilrijk Belgium;

    Zebrafishlab Veterinary Physiology and Biochemistry Department of Veterinary Sciences and Systemic Physiological and Ecotoxicological Research (SPHERE) Department of Biology University of Antwerp 2610 Wilrijk Belgium;

    United States Environmental Protection Agency Great Lakes Toxicology and Ecology Division Duluth Minnesota 55804 United States;

    United States Environmental Protection Agency Great Lakes Toxicology and Ecology Division Duluth Minnesota 55804 United States;

    United States Environmental Protection Agency Great Lakes Toxicology and Ecology Division Duluth Minnesota 55804 United States;

    Zebrafishlab Veterinary Physiology and Biochemistry Department of Veterinary Sciences University of Antwerp 2610 Wilrijk Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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