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首页> 外文期刊>Environmental Science & Technology >Cyanopeptide Co-Production Dynamics beyond Mirocystins and Effects of Growth Stages and Nutrient Availability
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Cyanopeptide Co-Production Dynamics beyond Mirocystins and Effects of Growth Stages and Nutrient Availability

机译：氰肽共同生产动力超出含致细胞素的和生长阶段的影响和营养可用性

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摘要

Intensified cyanobacterial bloom events are of increasing global concern because of adverse effects associated with the release of bioactive compounds, including toxic cyanopeptides. Cyanobacteria can produce a variety of cyanopeptides, yet our knowledge about their abundance and co-production remains limited. We applied a suspect-screening approach, including 700 structurally known cyanopeptides, and identified 11 cyanopeptides in Microcystis aeruginosa and 17 in Dolichospermum flos-aquae. Total cyanopeptide concentrations ranged from high nmol to μmiol g_(dry)~(-1) with slightly higher cell quotas in the mid-exponential growth phase. Relative cyanopeptide profiles were unchanged throughout the growth cycle. We demonstrate that quantification based on microcystin-LR equivalents can introduce an error of up to 6-fold and recommend a class-equivalent approach instead. In M. aeruginosa, rarely studied cyclamides dominated (＞80%) over cyanopeptolins and microcystins. While all nutrient reductions caused less growth, only lowering phosphorous and micronutrients reduced cyanopeptide production by M. aeruginosa. Similar trends were observed for D. flos-aquae and only lowering nitrogen decreased cyanopeptide production while the relative abundance of individual cyanopeptides remained stable. The synchronized production of other cyanopeptides along with microcystins emphasizes the need to make them available as reference standards to encourage more studies on their occurrence in blooms, persistence, and potential toxicity.
机译：由于与生物活性化合物的释放相关，包括毒性氰化物，增强的植物绽放事件具有增加的全球担忧。蓝藻可以产生各种氰化物，但我们对其丰富和共同生产的了解仍然有限。我们应用了可疑筛查方法，其中包括700种结构上已知的氰化物，并鉴定了微囊杆菌铜绿假单胞菌和17例中的11个氰庚酯，在Dolichospermum flos-apaae中。总氰肽浓度从高NMOL至μmiolg_（干）〜（-1）中，中指数生长阶段的细胞配额略高。相对氰肽曲线在整个生长循环中不变。我们证明基于微囊藻素-LR等效物的定量可以引入最多6倍的误差并推荐等效的方法。在M.铜绿假单胞菌中，很少研究用氰基氨基吡啶和微囊藻蛋白占据亚氨基胺（> 80％）。虽然所有营养减少均导致增长较低，但仅降低磷和微量营养素降低了M. eruginosa的氰肽产量。对于D. flos-aquae观察到类似的趋势，并且只有降低氮气降低氰肽生产，而单个氰化物的相对丰度保持稳定。其他氰肽的同步产生以及微囊藻蛋白强调需要使其作为参考标准作为参考标准，以鼓励更多的研究发生盛开，持续性和潜在毒性。

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  • 来源
    《Environmental Science & Technology》 |2020年第10期|6063-6072|共10页
  • 作者

    Regiane Natumi; Elisabeth M.-L. Janssen;

  • 作者单位

    Department of Environmental Chemistry Swiss Eederal Institute of Aquatic Science and Technology (Eawag) 8600 Duebendorf Switzerland;

    Department of Environmental Chemistry Swiss Federal Institute of Aquatic Science and Technology (Eawag) 8600 Duebendorf Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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