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首页> 外文期刊>Environmental Science & Technology >Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna
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Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna

机译：Eco-Corona vs蛋白质电晕：腐殖质物质对Daphnia Magna的电晕形成和纳米粒子粒子毒性的影响

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摘要

Despite many studies on the toxicity of nanoplastic particles (NPPs) to aquatic invertebrates, the effects of ecological constituents such as humic substances (HSs) are often neglected. In our study, Daphnia magna was used to evaluate the effects of three HSs, natural organic matter (NOM), fulvic acid (FA), and humic acid (HA), on NPP toxicity and corona formation. Acute toxicities of NPPs were reduced by all HSs at environmentally relevant concentrations. NPPs elicited the upregulation of all genes related to detoxification, oxidative stress, and endocrine activity after 7 days of exposure. The presence of NOM or HA resulted in the mitigation of gene expression, whereas significantly higher upregulation of all of the genes was observed with FA. The presence of FA led to increased protein adsorption on NPPs in D. magna culture medium (eco-corona, EC) and homogenates (protein corona, PC), while there was less adsorption in the presence of HA. The highly abundant proteins identified in EC are involved in immune defense, cell maintenance, and antipredator response, while those in PC are responsible for lipid transport, antioxidant effects, and estrogen mediation. Our findings revealed the key influence of HSs on the toxicity of NPPs and provide an analytical and conceptual foundation for future study.
机译：尽管对水生无脊椎动物的纳米塑料颗粒（NPPS）的毒性进行了许多研究，但经常忽略了生态成分（HSS）等生态成分的影响。在我们的研究中，Daphnia Magna用于评估三种HSS，天然有机物（NOM），富乙酸（FA）和腐殖酸（HA）的影响，对NPP毒性和电晕形成。所有HSS在环境相关浓度下都减少了NPP的急性毒性。 NPPS引发了在暴露7天后与排毒，氧化应激和内分泌活性有关的所有基因的上调。 NOM或HA的存在导致基因表达的减轻，而用FA观察到所有基因的显着更高的上调。 FA的存在导致D.Magna培养基（Eco-Corona，EC）和均质（蛋白质电晕，PC）上增加了蛋白质吸附，而在HA存在下吸附较少。 EC中鉴定的高度丰富蛋白质参与免疫防御，细胞维护和反向剂响应，而PC中的那些负责脂质传输，抗氧化效果和雌激素调解。我们的研究结果揭示了HSS对NPPS毒性的关键影响，为未来的研究提供了分析和概念性基础。

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  • 来源
    《Environmental Science & Technology》 |2020年第13期|8001-8009|共9页
  • 作者

    Oluniyi O. Fadare; Bin Wan; Keyang Liu; Yu Yang; Lixia Zhao; Liang-Hong Guo;

  • 作者单位

    Key Laboratory of Environmental Biotechnology and State Key Laboratory of Environmental Chemistry and Ecotoxkology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 People's Republic of China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 People's Republic of China;

    Key Laboratory of Environmental Biotechnology and State Key Laboratory of Environmental Chemistry and Ecotoxkology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 People's Republic of China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 People's Republic of China;

    Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 10008S People's Republic of China;

    State Key Laboratory of Environmental Chemistry and Ecotoxkology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 People's Republic of China;

    State Key Laboratory of Environmental Chemistry and Ecotoxkology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 People's Republic of China;

    Institute of Environmental and Health Sciences China Jiliang University Hangzhou Zhtjiang 310008 People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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