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首页> 外文期刊>Environmental Science & Technology >Does Low Maternal Exposure to Per- and Polyfluoroalkyl Substances Elevate the Risk of Spontaneous Preterm Birth? A Nested Case-Control Study in China
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Does Low Maternal Exposure to Per- and Polyfluoroalkyl Substances Elevate the Risk of Spontaneous Preterm Birth? A Nested Case-Control Study in China

机译：低母体暴露于每氟氟烷基物质和多氟烷基物质升高了自发早产的风险？中国嵌套案例控制研究

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摘要

Previous animal and human studies suggest potential links between maternal exposure to per- and polyfluoroalkyl substances (PFASs) and adverse birth outcomes. As spontaneous preterm birth (SPB) represents a major cause of infant mortality and precursor to future morbidity, we conducted a prospective nested case-control study in Shanxi Province, China to investigate the association between prenatal PFAS exposure and SPB risk, as well as the associations with biomarkers of oxidative stress and systemic inflammation. Among 4229 women enrolled during 2009-2013, 144 SPB cases and 375 controls were included in this study. Seventeen PFASs, as well as monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL- 8), and heme oxygenase-1 (HO-1), were measured in maternal plasma or serum collected during 4th-22nd gestational weeks. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and its alternative chlorinated polyfluoroether sulfonic acid (6:2 Cl-PFESA) were detected in more than 90% samples with a median concentration of 0.79, 1.79, and 0.34 ng/mL, respectively. The analyses revealed no significant associations between plasma PFASs and the SPB risk after adjusting for potential confounders. However, concentrations of PFOS and 6:2 Cl-PFESA were both significantly and positively associated with MCP-1 levels, while PFOA was inversely associated with IL-8. Our findings suggested that maternal exposure to the determined tow levels of PFAS did not induce an elevated risk of SPB, but the exposure may disturb potential biochemical pathways of inflammation. The latter has important implications for possible birth outcome effects and developmental effects in fetuses and newborns, which warrants close attention.
机译：以前的动物和人类研究表明母体接触和聚氟烷基物质（PFASS）和不良出生结果之间的潜在环节。由于自发早产（SPB）代表了婴儿死亡率和前身的主要原因，我们在中国山西省进行了一项前瞻性嵌套病例对照研究，探讨了产前PFAS暴露与SPB风险之间的关联，以及氧化应激和全身炎症的生物标志物的关联。在2009 - 2013年注册的4229名妇女中，本研究中纳入了144例SPB病例和375个对照。在第42个妊娠期收集的母体血浆或血清中测量17个PFASS，单核细胞化学侵入剂蛋白-1（MCP-1），白细胞介素-8（IL-8）和血红素氧酶-1（HO-1）。周。在大于90％的样品中检测到全氟辛酸（PFOA），全氟辛烷磺酸盐（PFOS）及其替代氯化多氟醚磺酸（6：2 CL-PFESA），中值浓度为0.79,1.79和0.34ng / ml，分别。分析显示，在调整潜在混淆后，血浆PFASS与SPB风险之间没有显着的关联。然而，PFOS和6：2 CL-PFESA的浓度显着且与MCP-1水平有显着且正相关，而PFOA与IL-8相反。我们的研究结果表明，Maternal暴露于确定的PFA的牵引水平没有诱导升高的SPB风险，但暴露可能会使炎症的潜在生化途径扰乱潜在的生化途径。后者对胎儿和新生儿的出生结果作用和发育效果具有重要意义，这是第一次关注的。

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  • 来源
    《Environmental Science & Technology》 |2020年第13期|8259-8268|共10页
  • 作者

    Xiaotu Liu; Da Chen; Bin Wang; Fangping Xu; Yiming Pang; Le Zhang; Yali Zhang; Lei Jin; Zhiwen Li; Aiguo Ren;

  • 作者单位

    School of Environment Guangdong Key Laboratory of Environmental Pollution and Health Jinan University Guangzhou 510632 China;

    School of Environment Guangdong Key Laboratory of Environmental Pollution and Health Jinan University Guangzhou 510632 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    School of Environment Guangdong Key Laboratory of Environmental Pollution and Health Jinan University Guangzhou 510632 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

    Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive Health National Health Commission of the People's Republic of China Beijing 100191 China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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