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首页> 外文期刊>Environmental Science & Technology >Uptake, Accumulation, and Biomarkers of PM_(2.5)-Associated Organophosphate Flame Retardants in C57BL/6 Mice after Chronic Exposure at Real Environmental Concentrations
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Uptake, Accumulation, and Biomarkers of PM_(2.5)-Associated Organophosphate Flame Retardants in C57BL/6 Mice after Chronic Exposure at Real Environmental Concentrations

机译：在真正的环境浓度下慢性暴露后C57BL / 6小鼠中PM_（2.5）的摄取，积聚和生物标志物 - 在C57BL / 6小鼠中的慢性暴露

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摘要

Although the bioaccumulation of organophosphate flame retardants (OPFRs) in aquatic organisms has been investigated, little information is available about their bioaccumulation in mammals following chronic inhalation exposure. To address this knowledge gap, CS7BL/6 mice were exposed to 7 PM_(2.5)-associated OPFRs via the trachea to study their bioaccumulation, tissue distribution, and urinary metabolites. Low (corresponding to the real PM_(2.5) concentrations occurring during winter in Guangzhou), medium, and high dosages were examined. After 72 days' exposure, ∑OPFR concentrations in tissues from mice in the medium dosage group decreased in the order of intestine ＞ heart ＞ stomach ＞ testis ＞ kidney ＞ spleen ＞ brain ＞ liver ＞ lung ＞ muscle. Of the OPFRs detected in all three exposure groups, chlorinated alkyl OPFRs were most heavily accumulated in mice. We found a significant positive correlation between the bioaccumulation ratio and octanol-air partition coefficient (K_(OA)) in mice tissues for low log K_(OW) OPFR congeners (log K_(OW) ≤ 4, p ＜ 0.05). Three urinary metabolites (di-p-cresyl phosphate: DCrP, diphenyl phosphate: DPhP, dibutyl phosphate: DnBP) were detected from the high dosage group. These results provide important insights into the bioaccumulation potential of OPFRs in mammals and emphasize the health risk of chlorinated alkyl OPFRs.
机译：虽然已经研究了有机磷酸盐阻燃剂（OPFRS）的生物累积在水生生物中，但在慢性吸入暴露后的哺乳动物中的生物累积很少。为了解决这种知识间隙，将CS7BL / 6小鼠通过气管暴露于7μm_（2.5） - 分配的OPFR，以研究其生物累积，组织分布和尿代谢物。低（对应于广州冬季发生的实际PM_（2.5）浓度），检查培养基和高剂量。经过72天的暴露后，中等剂量组小鼠组织中的ΣOpfr浓度按肠>心脏>胃>睾丸>肾>血液>脑>肝脏>肺癌>肺癌>肺癌>肺癌>肺癌>肌肉>肺部>肺部>肌肉。在所有三个曝光组中检测到的OPFR的氯化烷基OPFR在小鼠中最重质累积。我们发现低对数k_（OW）OPFR Congeners（Log K_（OW）≤4，P <0.05）的小鼠组织中的生物积累比和辛醇 - 空气分区系数（K_（OA））之间的显着正相关性。从高剂量基团检测到三种尿代谢物（二甲基甲酚：DCH，二苯基：DPHP，二丁基磷酸酯：DNBP）。这些结果对哺乳动物的OPFRS的生物积累潜力提供了重要的见解，并强调氯化烷基OPFR的健康风险。

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  • 来源
    《Environmental Science & Technology》 |2020年第15期|9519-9528|共10页
  • 作者

    Min Chen; Xiaoliang Liao; Shi-chao Yan; Yanpeng Gao; Chun Yang; Yuanyuan Song; Yi Liu; Weiquan Li; Suk-Ying Tsang; Zhi-Feng Chen; Zenghua Qi; Zongwei Cai;

  • 作者单位

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    State Key Laboratory of Environmental and Biological Analysis Department of Chemistry Hong Kong Baptist University Hong Kong China;

    College of Chemistry and Chemical Engineering Guangdong Pharmaceutical University Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    School of Life Sciences The Chinese University of Hong Kong Hong Kong China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China;

    Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and Engineering Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou 510006 China State Key Laboratory of Environmental and Biological Analysis Department of Chemistry Hong Kong Baptist University Hong Kong China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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