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首页> 外文期刊>Environmental Science & Technology >Adipose Tissue Transcriptome Is Related to Pollutant Exposure in Polar Bear Mother-Cub Pairs from Svalbard, Norway
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Adipose Tissue Transcriptome Is Related to Pollutant Exposure in Polar Bear Mother-Cub Pairs from Svalbard, Norway

机译：脂肪组织转录组与来自挪威斯瓦尔巴特的北极熊母亲 - 小熊对污染物暴露有关

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Being at the food chain apex, polar bears (Ursus maritimus) are highly contaminated with persistent organic pollutants (POPs). Females transfer POPs to their offspring through gestation and lactation; therefore, young cubs present higher POPs concentrations than their mothers. Recent studies suggest that POPs affect the lipid metabolism in female polar bears; however, the mechanisms and impact on their offspring remain unknown. Here, we hypothesized that exposure to POPs differentially alters genome-wide gene transcription in the adipose tissue from mother polar bears and their cubs, highlighting molecular differences in response between adults and young. Adipose tissue biopsies were collected from 13 adult female polar bears and their twin cubs in Svalbard, Norway, in April 2011, 2012, and 2013. Total RNA extracted from biopsies was subjected to next-generation RNA sequencing. Plasma concentrations of summed polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers in mothers ranged from 897 to 13620 ng/g wet weight and were associated with altered adipose tissue gene expression in both mothers and cubs. In mothers, 2502 and 2586 genes in total were positively and negatively, respectively, correlated to POP exposure, whereas in cubs, 2585 positively and 1690 negatively genes. Between mothers and cubs, 743 positively and negatively genes overlapped between mothers and cubs suggesting partially shared molecular responses to SPOPs. ZPOP-associated genes were involved in numerous metabolic pathways in mothers and cubs, indicating that POP exposure alters the energy metabolism, which, in turn, may be linked to metabolic dysfunction.
机译：在食物链顶点，北极熊（Ursus Maritimus）受到持久性有机污染物（POPS）的高度污染。女性通过妊娠和哺乳期间转移到他们的后代;因此，年轻的幼崽比母亲更高的汗水浓度。最近的研究表明，POPS影响女性北极熊中的脂质代谢;然而，对后代的机制和影响仍然是未知的。在这里，我们假设暴露于污染物差异地改变脂肪母熊及其幼崽的脂肪组织中的基因组基因转录，突出了成年人和年轻人之间的响应的分子差异。从2011年4月，2012年4月，从挪威的13名成年女性北熊及其双幼崽收集了脂肪组织活检。从活组织检查中提取的总RNA进行下一代RNA测序。求和多氯联苯，有机氯杀虫剂，和在母亲多溴二苯醚的血浆浓度范围为897至13620纳克/克湿重并具有改变的脂肪组织基因表达的母亲和幼仔相关联。在母亲中，总共2502和2586个基因分别是正面和消极的，与流行暴露相关，而在幼崽，2585次阳性和1690个负基因中。在母亲和幼崽之间，743个正面和负面的基因重叠，母亲和幼崽之间表明部分共用分子应对血症。 ZPOP相关基因涉及母亲和幼崽的许多代谢途径，表明POP暴露会改变能量代谢，又可以与代谢功能障碍相关联。

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  • 来源
    《Environmental Science & Technology》 |2020年第18期|11365-11375|共11页
  • 作者

    Pauline M. Herst; Jon Aars; Charles Joly Beauparlant; Antoine Bodein; Mathieu Dalvai; Dominic Gagne; Arnaud Droit; Janice L. Bailey; Heli Routti;

  • 作者单位

    Department of Animal Sciences Centre de Recherche en Reproduction D'eveloppement et Sante Intergen'erationnelle (CRDSl) Laval University Quebec City G1V 0A6 Canada;

    Norwegian Polar Institute NO-9296 Tromso Norway;

    Computational Biology Laboratory Research Centre Faculty of Medicine Laval University Quebec City G1V 0A6 Canada;

    Computational Biology Laboratory Research Centre Faculty of Medicine Laval University Quebec City G1V 0A6 Canada;

    Department of Animal Sciences Centre de Recherche en Reproduction Developpement et Sante Intergenerationnelle (CRDSl) Laval University Quebec City G1V 0A6 Canada;

    Department of Animal Sciences Centre de Recherche en Reproduction Developpement et Sante Intervenerationnelle (CRDSl) Laval University Quebec City G1V 0A6 Canada;

    Computational Biology Laboratory Research Centre Faculty of Medicine Laval University Quebec City G1V 0A6 Canada;

    Janice L. Bailey - Department of Animal Sciences Centre de Recherche en Reproduction Developpement et Sante Intergenerationnelle (CRDSI) Laval University Quebec City G1V 0A6 Canada;

    Norwegian Polar Institute NO-9296 Tromso Norway;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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