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首页> 外文期刊>Environmental Science & Technology >Response to Comment on 'Concentrations of Brominated Flame Retardants in Indoor Air and Dust from Ireland Reveal Elevated Exposure to Decabromodiphenyl Ethane'
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Response to Comment on 'Concentrations of Brominated Flame Retardants in Indoor Air and Dust from Ireland Reveal Elevated Exposure to Decabromodiphenyl Ethane'

机译：对评论对爱尔兰室内空气和灰尘中的溴化阻燃剂浓度的回应显示升高暴露于Decabromodhenyl乙烷'

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We thank Thomas Osimitz and coauthors for their letter regarding our paper entitled "Concentrations of Brominated Flame Retardants in Indoor Air and Dust from Ireland Reveal Elevated Exposure to Decabromodiphenyl Ethane", published last year (2019) in Environmental Science and Technology. We are grateful that they support our view that "High-end estimates of exposure to BDE-209 for Irish adults, toddlers, and school children are 100 ng/kg bw/day, 2500 ng/kg bw/day, and 1100 ng/kg/day, respectively, and below the USEPA reference dose (RfD) value for adults of 7000 ng/kg bw/day. Those for Octa-BDE (BDE-I83), Penta-BDE (BDE-47 and BDE-99), and ΣHBCDD are also below USEPA guidelines". We are also pleased that they highlight our previous work showing that exposure of some UK children to BDE-209 via indoor dust exceeds the USEPA's RfD. We also note that other researchers have suggested a much lower exposure limit for BDE-99, e.g., a maximal allowed intake level of 0.26 ng/kg bw/day. Moreover, in November 2017, the United Kingdom's Committee on Toxicity (UK COT) expressed "potential concern (about) BDE-99 and - 153 exposure from breast milk at age 12-18 months, and for exposure to BDE-99 and -209 in dust and soil in children aged 1-5 years". We further highlight that the RfD that Osimitz et al. applied for HBCDD of 200 μg/kg bw/day, was calculated by the National Academy of Sciences (NAS), using data from an unpublished subchronic study performed in rats in 1970. The NAS concluded that confidence in this RfD for HBCDD is low, because of a lack of other subchronic and chronic studies. Moreover, in October 2016, the UK COT stated that "high levels (of HBCDD) in household dust continues to be a cause for concern", citing a toxicological reference point of 3 μg/kg bw/day.
机译：我们感谢Thomas Osimitz和合唱团关于我们的纸质，题为“占据室内空气和爱尔兰尘埃的浓度溴化阻燃剂的浓度，揭示了Degabromodhenyl elehane”，去年（2019年）在环境科学和技术方面发表。我们非常感谢我们认为，我们认为，“爱尔兰成年人，幼儿和学童BDE-209的高端估计为100 Ng / kg Bw / day，2500 ng / kg bw / day，1100 ng /分别和低于USEPA参考剂量（RFD）值为7000ng / kg BW /天的kg /天。Octa-bde（BDE-I83），Penta-BDE（BDE-47和BDE-99）的那些，ΣHBCDD也低于USEPA指南“。我们也很高兴他们突出了我们以前的工作，表明，一些英国儿童通过室内粉尘将一些英国儿童暴露超过了USEPA的RFD。我们还注意到，其他研究人员已经提出了BDE-99的曝光极限，例如，例如，最大允许的进气水平为0.26 ng / kg bw /天。此外，2017年11月，英国毒性委员会（英国COT）表达了“潜在的关注（关于）BDE-99和-153母乳在12-18个月内接触，并接触BDE-99和-209在1-5岁的儿童灰尘和土壤中“。我们进一步强调了Osimitz等人的RFD。适用于200μg/ kg BW /天的HBCDD，由国家科学院（NAS）计算，使用来自1970年大鼠的未发表的次级研究的数据计算。NAS得出结论，对该抗植物率为HBCDD的信心低，由于缺乏其他次级和慢性研究。此外，在2016年10月，英国COT表示，家庭粉尘中的“高水平（HBCDD）仍然是令人担忧的原因”，引用毒理学参考点为3μg/ kg bw / day。

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