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首页> 外文期刊>Environmental Science & Technology >Considerations for Prioritization of Polycyclic Aromatic Compounds as Environmental Contaminants
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Considerations for Prioritization of Polycyclic Aromatic Compounds as Environmental Contaminants

机译：作为环境污染物的多环芳族化合物优先化的考虑

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摘要

Polycyclic aromatic compounds (PACs) as environmental contaminants have seen renewed interest by the global scientific community following a two-decade period where focus was primarily on halogenated persistent organic pollutants (POPs). However, biological systems, including humans, have continued to be exposed to large, if not greater than historical, quantities of PACs as urbanization/population expansion and an associated reliance on fossil fuels have continued to expand. The toxicity of PACs is well established. Effects typical of acute lethality (narcosis, oxidative stress), but also chronic and sublethal exposures leading to cancers, embryotoxicity (deformities; cardiotoxicity) and reproductive and metabolic endocrine disruption in vertebrates, are commonly reported following polycyclic aromatic hydrocarbon (PAH) exposure. Toxicity of PAHs is most widely recognized as a product of bioactivation of parent compounds (through phase Ⅰ and phase Ⅱ metabolisms) into genotoxic, carcinogenic, and reactive oxygenated metabolites. These reactions are universally mediated by the mixed function oxidase (MFO) family of enzymes such as cytochrome P450 (CYP). PAHs have the ability to alter CYP1 metabolic pathways upstream of CYP1 induction; an effect mediated by the aryl hydrocarbon receptor pathway (AhR). The activity of AhR and CYP in PAH metabolism has been studied extensively; however, PAC mixtures can also act through multiple biological pathways depending on dose and mixture components.
机译：多环芳香族化合物（PAC）作为环境污染物的兴趣在焦点主要涉及卤化持久性有机污染物（POPS）之后，全球科学界已以全球科学界再调整兴趣。然而，包括人类在内的生物系统继续暴露于大量，如果不大于历史，作为城市化/人口扩张和对化石燃料的相关依赖的花分的数量继续扩大。 PACS的毒性很好。急性致死率的典型效果（麻醉，氧化应激），但也导致癌症的慢性和亚麻暴露，胚胎毒性（畸形;心脏毒性）和脊椎动物的生殖和代谢内分泌破坏，常见于多环芳烃（PAH）暴露。 PAHS的毒性最广泛地被认为是母体化合物（通过Ⅰ期和Ⅱ期代谢）的生物活化的产物，进入遗传毒性，致癌和反应性含氧代谢物。这些反应普遍介导由混合函数氧化酶（MFO）族酶如细胞色素P450（CYP）。 PAHS有能力改变CYP1诱导上游CYP1代谢途径;由芳基烃受体途径（AHR）介导的效果。广泛研究了PAH代谢中AHR和CYP的活性;然而，PAC混合物还可以根据剂量和混合物组分通过多种生物途径作用。

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  • 来源
    《Environmental Science & Technology》 |2020年第23期|14787-14789|共3页
  • 作者

    C.H. Marvin; Gregg T. Tomy; Philippe J. Thomas; Alison C. Holloway; Court D. Sandau; Ifeoluwa Idowu; Zhe Xia;

  • 作者单位

    Water Science and Technology Directorate Environment and Climate Change Canada Burlington Ontario L7S 1A1 Canada;

    Centre for Oil and Gas Research and Development (COGRAD) University of Manitoba Winnipeg Manitoba R3T 2N2 Canada;

    Wildlife and Landscape Science Directorate Environment and Climate Change Canada Ottawa K1A 0H3 Canada;

    Department of Obstetrics and Gynecology McMaster University Hamilton Ontario L8N 3Z5 Canada;

    Chemistry Matters Inc. Calgary Alberta T2N 3P7 Canada;

    Centre for Oil and Gas Research and Development (COGRAD) University of Manitoba Winnipeg Manitoba R3T 2N2 Canada;

    Centre for Oil and Gas Research and Development (COGRAD) University of Manitoba Winnipeg Manitoba R3T 2N2 Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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