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首页> 外文期刊>Environmental Science & Technology >Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study
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Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

机译：在乳头甲状腺癌试验研究中，从个人硅树脂腕带中提取的化学物质的甲状腺受体对拮抗作用

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摘要

Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chemical mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chemical mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participating in a case-control study on papillary thyroid cancer. Sections of wristbands were solvent-extracted and analyzed via mass spectrometry to quantify a suite of semivolatile chemicals. A second extract from each wristband was used in a bioassay to quantify TRβ antagonism in human embryonic kidney cells (HEK293/17) at concentrations ranging from 0.1 to 10% of the original extract (by volume). Approximately 70% of the sample extracts tested at a 1% extract concentration exhibited significant TRβ antagonism, with a mean of 30% and a range of 0-100%. Inhibited cell viability was noted in >20% of samples that were tested at 5 and 10% concentrations. Antagonism was positively associated with wristband concentrations of several phthalates, organophosphate esters, and brominated flame retardants. These results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis. We also report tentative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyroid cancer case status. Future research utilizing larger sample sizes, prospective data collection, and measurement of serum thyroid hormone levels (which were not possible in this study) should be utilized to more comprehensively evaluate these associations.
机译：研究表明，甲状腺癌症发病率正在增加，环境暴露已经假定发挥作用。为了探讨这种可能性，我们进行了一项试验研究，以研究甲状腺癌队列中从个人硅树埋采样器中分离的化学混合物的甲状腺生物活性。具体而言，我们评估了在北卡罗来纳州中部地区成人佩戴的腕带（n = 72）提取的化学混合物的TRβ拮抗作用参与乳头状甲状腺癌的病例对照研究。腕带的部分是通过质谱分析的溶剂 - 提取和分析，以量化半溶解化学品套件。从每个腕带的第二次提取物用于生物测定中以​​在浓度为0.1-10％的原萃取物（体积）的浓度下量化人胚胎肾细胞（HEK293 / 17）中的Trβ拮抗作用。在1％提取物浓度下测试的约70％的样品提取物表现出显着的TRβ拮抗作用，其平均值为30％和0-100％。抑制的细胞活力在> 20％的样品中注意到在5和10％浓度下测试。拮抗作用与几种邻苯二甲酸酯，有机磷酸酯和溴化阻燃剂的腕带浓度正相关。这些结果表明个人被动采样器可用于评估人们每天联系的混合物的生物活性。我们还报告甲状腺受体拮抗作用，化学浓度和乳头状甲状腺癌病例状况的暂定关联。应利用利用较大样本尺寸，前瞻性数据收集和血清甲状腺激素水平测量的未来研究（在本研究中不可能），以更全面地评估这些关联。

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  • 来源
    《Environmental Science & Technology》 |2020年第23期|15296-15312|共17页
  • 作者

    Christopher D. Kassotis; Nicholas J. Herkert; Stephanie C. Hammel; Kate Hoffman; Qianyi Xia; Seth W. Kullman; Julie Ann Sosa; Heather M. Stapleton;

  • 作者单位

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

    Toxicology Program North Carolina State University Raleigh North Carolina 27695 United States;

    Department of Surgery University of California at San Francisco San Francisco California 94143 United States;

    Nicholas School of the Environment Duke University Durham North Carolina 27708 United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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