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首页> 外文期刊>Environmental Science & Technology >Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers
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Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers

机译：患有英语河流（Rutilus rut​​ilus）雌性溶解症患者致致致致致态污染的基因的调查

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摘要

Exposure of male fish to estrogenic substances from wastewater treatment works (WwTWs) results in feminization and reduced reproductive fitness. Nevertheless, self-sustaining populations of roach (Rutilus rutilus) inhabit river stretches polluted with estrogenic WwTW effluents. In this study, we examine whether such roach populations have evolved adaptations to tolerate estrogenic pollution by comparing frequency differences in single-nucleotide polymorphisms (SNPs) between populations sampled from rivers receiving either high- or low-level WwTW discharges. SNPs within 36 "candidate" genes, selected for their involvement in estrogenic responses, and 120 SNPs in reference genes were genotyped in 465 roaches. There was no evidence for selection in highly estrogen-dependent candidate genes, including those for the estrogen receptors, aromatases, and vitellogenins. The androgen receptor (ar) and cytochrome P450 1A genes were associated with large shifts in allele frequencies between catchments and in individual populations, but there is no clear link to estrogen pollution. Selection at ar in the effluent-dominated River Lee may have resulted from historical contamination with endocrine-disrupting pesticides. Critically, although our results suggest population-specific selection including at genes related to endocrine disruption, there was no strong evidence that the selection resulted from exposure to estrogen pollution.
机译：雄鱼暴露于来自废水处理工程（WWTWS）的雌激素物质导致女性化和减少生殖健康。然而，蟑螂（Rutilus rut​​ilus）的自我维持群体居住在雌激素的WWTW流出物中污染。在这项研究中，通过比较从接受高级或低水平的河流的群体之间的单核苷酸多态性（SNP）的频率差异，检查这种蟑螂种群是否已经进化了培养的适应性。在36“候选”基因中，SNP在465只蟑螂中选择参与雌激响应的参与和参考基因中的120只SNP。在高度雌激素依赖性候选基因中没有选择选择，包括雌激素受体，芳族酶和vitellogens的候选基因。雄激素受体（Ar）和细胞色素P450 1A基因与集水区内和个体种群之间的等位基因频率大的大变化相关，但没有明确的雌激素污染链接。在污水主导的河流李中的选择可能是历史污染与内分泌造成的杀虫剂造成的。批判性地，尽管我们的结果表明群体特异性选择，包括在与内分泌破坏相关的基因中，但没有强有力的证据表明选择因暴露于雌激素污染而导致。

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  • 来源
    《Environmental Science & Technology》 |2020年第24期|15935-15945|共11页
  • 作者

    Patrick B. Hamilton; Anne E. Lockyer; Tamsyn M. Uren Webster; David J. Studholme; Josephine R. Paris; Alice Baynes; Elizabeth Nicol; Deborah A. Dawson; Karen Moore; Audrey Farbos; Susan Jobling; Jamie R. Stevens; Charles R. Tyler;

  • 作者单位

    Bioscknces College of Life and Environmental Sciences and College of Medicine and Health University of Exeter Exeter EX4 4QD U.K.;

    Institute of Environment Health and Societies Brunei University London Uxbridge Middlesex UBS 3PH U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K. Biosciences College of Science Swansea University Swansea SA2 8PP U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

    Institute of Environment Health and Societies Brunei University London Uxbridge Middlesex UBS 3PH U.K.;

    Institute of Environment Health and Societies Brunei University London Vxbridge Middlesex UBS 3PH U.K.;

    NERC Biomolecular Analysis Facility Department of Animal and Plant Sciences University of Sheffield Sheffield S10 2TN U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

    Institute of Environment Health and Societies Brunei University London Uxbridge Middlesex UBS 3PH U.K.;

    Biosciences College of Life and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

    Biosciences College of Lije and Environmental Sciences University of Exeter Exeter EX4 4QD U.K.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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