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Ecotoxicology Goes on a Chip: Embracing Miniaturized Bioanalysis in Aquatic Risk Assessment

机译:生态毒理学在芯片上:将微型生物分析纳入水生风险评估

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摘要

Biological and environmental sciences are, more than ever, becoming highly dependent on technological and multidisciplinary approaches that warrant advanced analytical capabilities. Microfluidic lab-on-a-chip technologies are perhaps one the most groundbreaking offshoots of bioengineering, enabling design of an entirely new generation of bioanalytical instrumentation. They represent a unique approach to combine microscale engineering and physics with specific biological questions, providing technological advances that allow for fundamentally new capabilities in the spatiotemporal analysis of molecules, cells, tissues, and even small metazoan organisms. While these miniaturized analytical technologies experience an explosive growth worldwide, with a substantial promise of a direct impact on biosciences, it seems that lab-on-a-chip systems have so far escaped the attention of aquatic ecotoxicologists. In this Critical Review, potential applications of the currently existing and emerging chip-based technologies for aquatic ecotoxicology and water quality monitoring are highlighted. We also offer suggestions on how aquatic ecotoxicology can benefit from adoption of microfluidic lab-on-a-chip devices for accelerated bioanalysis.
机译:生物和环境科学比以往任何时候都更加依赖需要先进分析能力的技术和多学科方法。微流控芯片实验室技术可能是生物工程学中最突破性的分支之一,可以设计出新一代的生物分析仪器。它们代表了一种将微观工程学和物理学与特定生物学问题相结合的独特方法,其技术进步为分子,细胞,组织乃至小型后生生物的时空分析提供了根本上的新功能。尽管这些小型分析技术在全球范围内经历了爆炸式增长,并有望对生物科学产生直接影响,但迄今为止,单芯片实验室系统似乎已经摆脱了水生生态毒理学家的关注。在本重要评论中,着重介绍了目前用于水生生态毒理学和水质监测的基于芯片的技术的潜在应用。我们还提供有关如何通过采用微流控芯片实验室设备进行加速生物分析而使水生生态毒理学受益的建议。

著录项

  • 来源
    《Environmental Science & Technology》 |2018年第3期|932-946|共15页
  • 作者单位

    Instituto de Ciencias Marinas de Andalucía, CSIC, Puerto Real, 11519, Spain;

    School of Science, RMIT University, Melbourne, Victoria 3083, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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