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首页> 外文期刊>Environmental Science & Technology >Comparative Cardiopulmonary Effects of Particulate Matter- And Ozone-Enhanced Smog Atmospheres in Mice
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Comparative Cardiopulmonary Effects of Particulate Matter- And Ozone-Enhanced Smog Atmospheres in Mice

机译：小鼠颗粒物质和臭氧增强烟雾气氛的比较心肺作用

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摘要

This study was conducted to compare the cardiac effects of particulate matter (PM)- (SA-PM) and ozone(O_(3))-enhanced (SA-O_(3)) smog atmospheres in mice. Based on our previous findings of filtered diesel exhaust we hypothesized that SA-O_(3) would cause greater cardiac dysfunction than SA-PM. Radiotelemetered mice were exposed to either SA-PM, SA-O_(3), or filtered air (FA) for 4 h. Heart rate (HR) and electrocardiogram were recorded continuously before, during and after exposure. Both SA-PM and SA-O_(3) increased heart rate variability (HRV) but only SA-PM increased HR. Normalization of responses to total hydrocarbons, gas-only hydrocarbons and PM concentration were performed to assess the relative contribution of each phase given the compositional variability. Normalization to PM concentration revealed that SA-O_(3) was more potent in increasing HRV, arrhythmogenesis, and causing ventilatory changes. However, there were no differences when the responses were normalized to total or gas-phase only hydrocarbons. Thus, this study demonstrates that a single exposure to smog causes cardiac effects in mice. Although the responses of SA-PM and SA-O_(3) are similar, the latter is more potent in causing electrical disturbances and breathing changes potentially due to the effects of irritant gases, which should therefore be accounted for more rigorously in health assessments.
机译：进行这项研究来比较颗粒物（PM）-（SA-PM）和臭氧（O_（3））-增强的（SA-O_（3））烟雾环境对小鼠的心脏影响。根据我们先前对过滤后的柴油机排气的发现，我们假设SA-O_（3）会比SA-PM引起更大的心脏功能障碍。无线电遥测的小鼠暴露于SA-PM，SA-O_（3）或过滤空气（FA）4小时。在暴露之前，期间和之后连续记录心率（HR）和心电图。 SA-PM和SA-O_（3）均会增加心率变异性（HRV），但只有SA-PM会增加心率。对总烃，仅含气烃和PM浓度的响应进行归一化，以评估给定组成变异性下各相的相对贡献。对PM浓度的归一化显示SA-O_（3）在增加HRV，心律失常和引起通气改变方面更有效。但是，将响应归一化为总烃或仅气相烃时，没有差异。因此，这项研究表明，一次接触烟雾会引起小鼠心脏疾病。尽管SA-PM和SA-O_（3）的响应相似，但后者在引起电干扰和呼吸变化方面更有效，这可能是由于刺激性气体的影响，因此在健康评估中应更严格地加以考虑。

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  • 来源
    《Environmental Science & Technology》 |2018年第5期|3071-3080|共10页
  • 作者

    Mehdi S. Hazari; Kimberly M. Stratford; Q. Todd Krantz; Charly King; Jonathan Krug; Aimen K. Farraj; M. Ian Gilmour;

  • 作者单位

    Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Curriculum in Toxicology, University of North Carolina − Chapel Hill, Chapel Hill, North Carolina 27599, United States;

    Inhalation Toxicology Facilities Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Inhalation Toxicology Facilities Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Exposure Methods and Measurement Division, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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