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首页> 外文期刊>Environmental Science & Technology >Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish (Danio rerio)
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Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish (Danio rerio)

机译：从水力压裂回流和采出水到斑马鱼（Danio rerio）早期生命阶段的有机组分的发育毒性。

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Hydraulic fracturing (HF) has emerged as a major recovery method of unconventional oil and gas reservoirs and concerns have been raised regarding the environmental impact of releases of Flowback and Produced Water (FPW) to aquatic ecosystems. To investigate potential effects of HF-FPW on fish embryo development, HF-FPW samples were collected from two different wells and the organic fractions were isolated from both aqueous and particle phases to eliminate the confounding effects of high salinity. Each organic extract was characterized by non-target analysis with HPLC-Orbitrap-MS, with targeted analysis for polycyclic aromatic hydrocarbons provided as markers of petroleum-affected water. The organic profiles differed between samples, including PAHs and alkyl PAHs, and major substances identified by non-target analysis included polyethylene glycols, alkyl ethoxylates, octylphenol ethoxylates, and other high molecular weight (C_(49–79)) ethylene oxide polymeric material. Zebrafish embryos were exposed to various concentrations of FPW organic extracts to investigate acute (7-day) and developmental toxicity in early life stages. The acute toxicity (LD_(50)) of the extracted FPW fractions ranged from 2.8× to 26× the original organic content. Each extracted FPW fraction significantly increased spinal malformation, pericardial edema, and delayed hatch in exposed embryos and altered the expression of a suite of target genes related to biotransformation, oxidative stress, and endocrine-mediation in developing zebrafish embryos. These results provide novel information on the variation of organic profiles and developmental toxicity among different sources and fractions of HF-FPWs.
机译：水力压裂（HF）已成为非常规油气藏的一种主要回收方法，并且人们对将回流和产出水（FPW）释放到水生生态系统中的环境产生了关注。为了研究HF-FPW对鱼胚发育的潜在影响，从两个不同的井中收集HF-FPW样品，并从水相和颗粒相中分离出有机部分，以消除高盐度的混杂效应。每种有机提取物的特征均采用HPLC-Orbitrap-MS进行非目标分析，并针对多环芳烃进行目标分析，以作为石油影响水的标志物。样品之间的有机特性有所不同，包括PAH和烷基PAH，通过非目标分析鉴定的主要物质包括聚乙二醇，烷基乙氧基化物，辛基酚乙氧基化物和其他高分子量（C_（49-79））环氧乙烷聚合物。将斑马鱼胚胎暴露于各种浓度的FPW有机提取物中，以研究生命早期的急性（7天）和发育毒性。提取的FPW组分的急性毒性（LD_（50））为原始有机物含量的2.8倍至26倍。每个提取的FPW组分都会显着增加裸露的胚胎中的脊髓畸形，心包水肿和延迟孵化，并改变了与发育中的斑马鱼胚胎中与生物转化，氧化应激和内分泌介导有关的一系列靶基因的表达。这些结果提供了有关HF-FPW的不同来源和馏分之间有机特征变化和发育毒性的新信息。

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  • 来源
    《Environmental Science & Technology》 |2018年第6期|3820-3830|共11页
  • 作者

    Yuhe He; Chenxing Sun; Yifeng Zhang; Erik J. Folkerts; Jonathan W. Martin; Greg G. Goss;

  • 作者单位

    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada;

    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada;

    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada;

    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada;

    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada;

    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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