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首页> 外文期刊>Environmental Science & Technology >Enantioselective Effects of Metalaxyl Enantiomers in Adolescent Rat Metabolic Profiles Using NMR-Based Metabolomics
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Enantioselective Effects of Metalaxyl Enantiomers in Adolescent Rat Metabolic Profiles Using NMR-Based Metabolomics

机译：甲霜灵对映异构体对青少年大鼠代谢谱中基于核磁共振的代谢组学的对映选择性作用。

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摘要

More than 30% of the registered pesticides are chiral with one or more chiral centers and exist as two or more enantiomers. The frequency of chiral chemicals and their environmental safety has been considered in their risk assessment in recent decades. Despite the fact that metabolic disturbance is an important sensitive molecular initiating event of toxicology effects, the potential mechanisms of how chiral compounds affect metabolism phenotypes in organisms remain unclear. As a typical chiral pesticide, metalaxyl is an acylalanine fungicide with systemic function. Although the fungicidal activity almost comes from the R -enantiomer, the toxicity of both enantiomers in animals and human beings is not yet clear. In this study, a nuclear magnetic resonance (NMR)-based metabolomics approach was adopted to evaluate the enantioselectivity in metabolic perturbations in adolescent rats. On the basis of multivariate statistical results, stable and evident metabolic profiles of the enantiomers were obtained. When rats were exposed to R -metalaxyl, the significantly perturbed metabolic pathways were biosynthesis of valine, leucine, and isoleucine, synthesis and degradation of ketone bodies, and metabolism of glycerolipid. In contrast, more significantly perturbed metabolic pathways were obtained when the rats were exposed to S -metalaxyl, including glycolysis, biosynthesis of valine, leucine, and isoleucine, metabolism of glycine, serine, and threonine, synthesis and degradation of ketone bodies, metabolism of glycerophospholipid and glycerolipid. These abnormal metabolic pathways were closely related to liver metabolism. These results offer more detailed information about the enantioselective metabolic effects of metalaxyl in adolescent development and provide data for the health risk assessment of metalaxyl at molecular level.
机译：超过30％的注册农药是具有一个或多个手性中心的手性化合物，并且以两种或多种对映体的形式存在。近几十年来，在手性化学品的风险评估中已经考虑了手性化学品的使用频率及其环境安全性。尽管代谢紊乱是毒理学效应的重要的敏感分子引发事件，但手性化合物如何影响生物体内代谢表型的潜在机制仍不清楚。作为典型的手性农药，甲霜灵是一种具有全身功能的酰基丙氨酸杀真菌剂。尽管杀真菌活性几乎来自R-对映异构体，但是对映异构体在动物和人类中的毒性尚不清楚。在这项研究中，采用了基于核磁共振（NMR）的代谢组学方法来评估青春期大鼠代谢扰动中的对映选择性。基于多元统计结果，获得了对映异构体的稳定和明显的代谢特征。当大鼠暴露于R-甲霜灵时，明显受干扰的代谢途径是缬氨酸，亮氨酸和异亮氨酸的生物合成，酮体的合成和降解以及甘油脂的代谢。相反，当大鼠暴露于i-甲霜灵时，代谢途径更为明显，包括糖酵解，缬氨酸，亮氨酸和异亮氨酸的生物合成，甘氨酸，丝氨酸和苏氨酸的代谢，酮体的合成和降解。 ，甘油磷脂和甘油脂的代谢。这些异常的代谢途径与肝脏代谢密切相关。这些结果提供了有关甲霜灵对青少年发育的对映选择性代谢作用的更详细的信息，并为甲霜灵在分子水平上的健康风险评估提供了数据。

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  • 来源
    《Environmental Science & Technology》 |2018年第9期|5438-5447|共10页
  • 作者

    Jinping Gu; Chenyang Ji; Siqing Yue; Dan Shu; Feng Su; Yinjun Zhang; Yuanyuan Xie; Yi Zhang; Weiping Liu; Meirong Zhao;

  • 作者单位

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

    College of Environment & Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    College of Pharmaceutical Sciences, Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, and College of Biological Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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