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首页> 外文期刊>Environmental Science & Technology >Deriving in Vivo Bioconcentration Factors of a Mixture of Fragrance Ingredients Using a Single Dietary Exposure and Internal Benchmarking
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Deriving in Vivo Bioconcentration Factors of a Mixture of Fragrance Ingredients Using a Single Dietary Exposure and Internal Benchmarking

机译：使用单一饮食暴露和内部基准比较得出香气成分混合物的体内生物浓缩因子

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摘要

Chemicals in mixtures that are hydrophobic with Log K _(OW) > 4 are potentially bioaccumulative. Here, we evaluate an abbreviated and benchmarked in vivo BCF measurement methodology by exposing rainbow trout to a mixture of eight test chemicals found in fragrance substances and three benchmark chemicals (musk xylene (MX), hexachlorobenzene (HCB) and PCB52) via a single contaminated feeding event followed by a 28-day depuration period. Concentrations of HCB and PCB52 in fish did not decline significantly (their apparent depuration rate constants, k _(T), were close to zero), whereas k _(T) for MX was 0.022 d~(–1). The test chemicals were eliminated much more rapidly than the benchmark chemicals (k _(T) > 0.117 d~(–1)). The bioconcentration factors (BCF_(A)) for the test chemicals were in the range of 273 L kg~(–1) (8-cyclohexadecen-1-one (globanone)) to 1183 L kg~(–1) (α-pinene); the benchmarked BCFs (BCF_(G)) calculated relative to HCB ranged from 238 L kg~(–1) (globanone) to 1147 L kg~(–1) (α-pinene). BCF_(G) were not significantly different from BCF_(A) but had smaller standard errors. BCFs derived here agreed well with values previously measured using the OECD 305 test protocol. We conclude that it will be feasible to derive BCFs of chemicals in mixtures using a single dietary exposure and chemical benchmarking.
机译：具有Log K（OW）> 4的疏水性混合物中的化学物质可能具有生物蓄积性。在这里，我们通过将虹鳟鱼暴露于经过单一污染的八种香精物质中发现的八种测试化学品与三种基准化学品（麝香二甲苯（MX），六氯苯（HCB）和PCB52）的混合物中，从而评估了一种简化的基准BCF体内测量方法喂食事件，随后是28天的净化期。鱼中六氯代苯和多氯联苯52的浓度没有显着下降（它们的表观净化速率常数 k _（T）接近零），而MX的k __（T）为0.022 d〜（– 1）。与基准化学品相比，消除了测试化学品的速度要快得多（k_（T）> 0.117 d〜（-1））。被测化学品的生物浓缩系数（BCF_（A））在273 L kg〜（–1）（8-环十六烯-1-一（球蛋白））至1183 L kg〜（–1）（α- ene烯）;相对于六氯代苯计算的基准BCF（BCF_（G））范围从238 L kg〜（-1）（球蛋白）到1147 L kg〜（-1）（α-pine烯）。 BCF_（G）与BCF_（A）并无显着差异，但标准误差较小。此处得出的BCF与先前使用OECD 305测试协议测得的值非常吻合。我们得出结论，使用单一饮食暴露和化学基准确定混合物中化学成分的BCF是可行的。

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  • 来源
    《Environmental Science & Technology》 |2018年第9期|5227-5235|共9页
  • 作者

    Chang-Er L. Chen; Karin Löfstrand; Margaretha Adolfsson-Erici; Michael S. McLachlan; Matthew MacLeod;

  • 作者单位

    Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden;

    Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden;

    Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden;

    Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden;

    Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-106 91 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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