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首页> 外文期刊>Environmental Science & Technology >Halobenzoquinone-Induced Alteration of Gene Expression Associated with Oxidative Stress Signaling Pathways
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Halobenzoquinone-Induced Alteration of Gene Expression Associated with Oxidative Stress Signaling Pathways

机译：卤代苯醌诱导的氧化应激信号通路相关基因表达的改变

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摘要

Halobenzoquinones (HBQs) are emerging disinfection byproducts (DBPs) that effectively induce reactive oxygen species and oxidative damage in vitro. However, the impacts of HBQs on oxidative-stress-related gene expression have not been investigated. In this study, we examined alterations in the expression of 44 genes related to oxidative-stress-induced signaling pathways in human uroepithelial cells (SV-HUC-1) upon exposure to six HBQs. The results show the structure-dependent effects of HBQs on the studied gene expression. After 2 h of exposure, the expression levels of 9 to 28 genes were altered, while after 8 h of exposure, the expression levels of 29 to 31 genes were altered. Four genes (HMOX1 , NQO1 , PTGS2 , and TXNRD1 ) were significantly upregulated by all six HBQs at both exposure time points. Ingenuity pathway analysis revealed that the Nrf2 pathway was significantly responsive to HBQ exposure. Other canonical pathways responsive to HBQ exposure included GSH redox reductions, superoxide radical degradation, and xenobiotic metabolism signaling. This study has demonstrated that HBQs significantly alter the gene expression of oxidative-stress-related signaling pathways and contributes to the understanding of HBQ-DBP-associated toxicity.
机译：卤代苯醌（HBQ）是新兴的消毒副产物（DBP），可在体外有效诱导活性氧和氧化损伤。但是，尚未研究HBQ对氧化应激相关基因表达的影响。在这项研究中，我们研究了暴露于六个HBQs后人尿道上皮细胞（SV-HUC-1）中与氧化应激诱导的信号通路相关的44个基因的表达变化。结果表明HBQs对研究的基因表达的结构依赖性的影响。暴露2小时后，9至28个基因的表达水平发生了变化，而暴露8小时后，29至31个基因的表达水平发生了变化。在两个暴露时间点，所有六个HBQ均显着上调了四个基因（HMOX1，NMQ1，PTGS2和TXNRD1）。独创性途径分析显示，Nrf2途径对HBQ暴露有显着响应。对HBQ暴露有反应的其他典型途径包括GSH氧化还原减少，超氧化物自由基降解和异源代谢信号。这项研究表明，HBQs显着改变了氧化应激相关信号通路的基因表达，并有助于对HBQ-DBP相关毒性的理解。

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  • 来源
    《Environmental Science & Technology》 |2018年第11期|6576-6584|共9页
  • 作者

    Jinhua Li; Birget Moe; Yanming Liu; Xing-Fang Li;

  • 作者单位

    Department of Health Toxicology, School of Public Health, Jilin University, Changchun, Jilin, China 130021,Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G3;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G3,Alberta Centre for Toxicology, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G3;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G3;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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