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首页> 外文期刊>Environmental Science & Technology >Suspect Screening and Regulatory Databases: A Powerful Combination To Identify Emerging Micropollutants
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Suspect Screening and Regulatory Databases: A Powerful Combination To Identify Emerging Micropollutants

机译：可疑筛查和监管数据库：识别新兴的微污染物的强大组合

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摘要

This study demonstrates that regulatory databases combined with the latest advances in high resolution mass spectrometry (HRMS) can be efficiently used to prioritize and identify new, potentially hazardous pollutants being discharged into the aquatic environment. Of the approximately 23000 chemicals registered in the database of the National Swedish Product Register, 160 potential organic micropollutants were prioritized through quantitative knowledge of market availability, quantity used, extent of use on the market, and predicted compartment-specific environmental exposure during usage. Advanced liquid chromatography (LC)–HRMS-based suspect screening strategies were used to search for the selected compounds in 24 h composite samples collected from the effluent of three major wastewater treatment plants (WWTPs) in Sweden. In total, 36 tentative identifications were successfully achieved, mostly for substances not previously considered by environmental scientists. Of these substances, 23 were further confirmed with reference standards, showing the efficiency of combining a systematic prioritization strategy based on a regulatory database and a suspect-screening approach. These findings show that close collaboration between scientists and regulatory authorities is a promising way forward for enhancing identification rates of emerging pollutants and expanding knowledge on the occurrence of potentially hazardous substances in the environment.
机译：这项研究表明，监管数据库与高分辨率质谱（HRMS）的最新进展相结合，可以有效地用于确定优先级并确定排入水生环境的新的，潜在的有害污染物。在瑞典国家产品注册数据库中注册的大约23000种化学药品中，通过对市场可用性，使用量，市场使用范围以及使用过程中预计的隔室特定环境暴露的定量了解，对160种潜在的有机微量污染物进行了优先排序。先进的液相色谱（LC）–基于HRMS的可疑筛查策略用于在24小时复合样品中搜索选定的化合物，这些样品是从瑞典三个主要废水处理厂（WWTP）的废水中收集的。总共成功地完成了36个初步鉴定，主要是环境科学家以前未考虑过的物质。在这些物质中，有23种已通过参考标准进一步确认，显示了结合基于监管数据库和可疑筛查方法的系统优先策略的效率。这些发现表明，科学家与监管机构之间的密切合作是提高新出现的污染物的识别率和扩大对环境中潜在有害物质的认识的有前途的方法。

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  • 来源
    《Environmental Science & Technology》 |2018年第12期|6881-6894|共14页
  • 作者

    Pablo Gago-Ferrero; Agnes Krettek; Stellan Fischer; Karin Wiberg; Lutz Ahrens;

  • 作者单位

    Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-75007 Uppsala, Sweden;

    Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-75007 Uppsala, Sweden,Institute of Soil Science and Land Evaluation, Soil Chemistry and Pedology, University of Hohenheim, Emil-Wolff-Straße 27, 70599 Stuttgart, Germany;

    The Swedish Chemicals Agency (KemI), SE-172 67 Stockholm, Sweden;

    Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-75007 Uppsala, Sweden;

    Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-75007 Uppsala, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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