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Screening Priority Factors Determining and Predicting the Reproductive Toxicity of Various Nanoparticles

机译：筛选确定和预测各种纳米粒子生殖毒性的优先因素

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摘要

Due to the numerous factors (e.g., nanoparticle [NP] properties and experimental conditions) influencing nanotoxicity, it is difficult to identify the priority factors dominating nanotoxicity. Herein, by integrating data from the literature and a random forest model, the priority factors determining reproductive toxicity were successfully screened from highly heterogeneous data. Among 10 factors from more than 18 different NPs, the NP type and the exposure pathway were found to dominantly determine NP accumulation. The reproductive toxicity of various NPs primarily depended on the NP type and the toxicity indicators. Nanoparticles containing major elements (e.g., Zn and Fe) tended to accumulate in rats but induced lower toxicity than NPs containing noble elements. Compared with other exposure pathways, i.p. injection posed significantly higher risks for NP accumulation. By combining similarity network analysis and hierarchical clustering, the sources of highly heterogeneous data were identified, the factor-toxicity dependencies were extracted and visualized, and the prediction of nanotoxicity was then achieved based on the screened priority factors. The present work provides insights for the design of animal experiments and the illustration and prediction of nanotoxicity.
机译：由于影响纳米毒性的因素众多（例如，纳米粒子[NP]的性质和实验条件），因此难以确定主导纳米毒性的优先因素。本文中，通过整合来自文献和随机森林模型的数据，成功地从高度异质性数据中筛选出决定生殖毒性的优先因素。在来自18个以上不同NP的10个因素中，发现NP类型和暴露途径是决定NP积累的主要因素。各种NP的生殖毒性主要取决于NP类型和毒性指标。含有主要元素（例如Zn和Fe）的纳米颗粒倾向于在大鼠中蓄积，但其毒性低于含有贵族元素的NP。与其他暴露途径相比注射会大大增加NP积累的风险。通过相似度网络分析和层次聚类相结合，识别出高度异质的数据源，提取并可视化因子-毒性相关性，然后基于筛选出的优先因子实现对纳米毒性的预测。本工作为动物实验的设计以及纳米毒性的说明和预测提供了见识。

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  • 来源
    《Environmental Science & Technology》 |2018年第17期|9666-9676|共11页
  • 作者

    Ban Zhan; Zhou Qixing; Sun Anqi; Mu Li; Hu Xiangang;

  • 作者单位

    Nankai Univ, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin Key Lab Environm Remediat & Pollut Contro, Tianjin 300350, Peoples R China;

    Nankai Univ, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin Key Lab Environm Remediat & Pollut Contro, Tianjin 300350, Peoples R China;

    Nankai Univ, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin Key Lab Environm Remediat & Pollut Contro, Tianjin 300350, Peoples R China;

    Minist Agr, Tianjin Key Lab Agroenvironm & Agroprod Safety, Key Lab Environm Factors Control Agroprod Qual &, Inst Agroenvironm Protect, Tianjin 300191, Peoples R China;

    Nankai Univ, Key Lab Pollut Proc & Environm Criteria, Minist Educ,Coll Environm Sci & Engn, Tianjin Key Lab Environm Remediat & Pollut Contro, Tianjin 300350, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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