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首页> 外文期刊>Environmental Science & Technology >Disruption of the Prostaglandin Metabolome and Characterization of the Pharmaceutical Exposome in Fish Exposed to Wastewater Treatment Works Effluent As Revealed by Nanoflow-Nanospray Mass Spectrometry-Based Metabolomics
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Disruption of the Prostaglandin Metabolome and Characterization of the Pharmaceutical Exposome in Fish Exposed to Wastewater Treatment Works Effluent As Revealed by Nanoflow-Nanospray Mass Spectrometry-Based Metabolomics

机译：纳米流-基于纳米喷雾质谱的代谢组学揭示了暴露于污水处理厂废水中的鱼类中前列腺素代谢组的破坏和药物外显子的表征

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摘要

Fish can be exposed to a complex mixture of chemical contaminants, including pharmaceuticals, present in discharges of wastewater treatment works (WwTWs) effluents. There is little information on the effects of effluent exposure on fish metabolism, especially the small molecule signaling compounds which are the biological target of many pharmaceuticals. We applied a newly developed sensitive nanoflow-nanospray mass spectrometry nontargeted profing technique to identify changes in the exposome and metabolome of roach (Rutilus rutilus) exposed to a final WwTWs effluent for 15 days. Effluent exposure resulted in widespread reduction (between 50% and 90%) in prostaglandin (PG) profiles in fish tissues and plasma with disruptions also in tryptophan/serotonin, bile acid and lipid metabolism. Metabolite disraptions were not explained by altered expression of genes associated with the PG or tryptophan metabolism. Of the 31 phannaceuticai metabolites that were detected in the effluent exposome of fish, 6 were nonsteroidal anti-inflammatory drugs but with plasma concentrations too low to disrupt PG biosynthesis. PGs, bile acids, and tryptophan metabolites are important mediators regulating a diverse array of physiological systems in fish and the identity of wastewater contaminants disrapting their metabolism warrants further investigation on their exposure effects on fish health.
机译：鱼可能会暴露于废水处理厂（WwTWs）废水中存在的化学污染物（包括药品）的复杂混合物中。关于污水暴露对鱼类代谢的影响的信息很少，尤其是作为许多药物的生物学目标的小分子信号化合物。我们应用了新开发的灵敏的纳米流-纳喷雾质谱非靶向分析技术，以鉴定暴露于最终WwTWs废水15天的蟑螂（Rutilus rut​​ilus）的暴露和代谢组的变化。污水暴露导致鱼组织和血浆中前列腺素（PG）分布广泛降低（在50％至90％之间），色氨酸/ 5-羟色胺，胆汁酸和脂质代谢也受到破坏。不能通过与PG或色氨酸代谢相关的基因表达的改变来解释代谢物的分散。在鱼的流出液中检测到的31种拟南芥代谢产物中，有6种是非甾体类抗炎药，但血浆浓度过低而无法破坏PG的生物合成。 PG，胆汁酸和色氨酸代谢物是调节鱼中各种生理系统的重要介质，而破坏其代谢的废水污染物的身份也需要进一步研究其对鱼类健康的影响。

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  • 来源
    《Environmental Science & Technology》 |2017年第1期|616-624|共9页
  • 作者

    Arthur David; Anke Lange; Alaa Abdul-Sada; Charles R. Tyler; Elizabeth M. Hill;

  • 作者单位

    School of Life Sciences. University of Sussex. Brighton. U.K. BN1 9QG;

    Biosciences, College of Life & Environmental Sciences. University of Exeter, Exeter. U.K. EX4 4QD;

    School of Life Sciences. University of Sussex. Brighton. U.K. BN1 9QG;

    Biosciences, College of Life & Environmental Sciences. University of Exeter, Exeter. U.K. EX4 4QD;

    School of Life Sciences. University of Sussex. Brighton. U.K. BN1 9QG;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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