...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Fine Particulate Constituents and Lung Dysfunction: A Time-Series Panel Study
【24h】

Fine Particulate Constituents and Lung Dysfunction: A Time-Series Panel Study

机译：细颗粒成分和肺功能障碍：时间序列面板研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The evidence is quite limited regarding the constituents of fine particilate matter (PM_(2.5)) responsible for lung dysfunction. We designed a time-series panel study in 28 patients to examine the effects of 10 major constituents of PM_(2.5) on lung function with repeated daily measurements from December 2012 to May 2013 in Shanghai, China. We applied a linear mixed-effect model combined with a distributed lag model to estimate the cumulative efiects of PM_(2.5) constituents on morning/evening forced expiratory volume in 1-s (FEV_1) and peak expiratory flow (PEF) over a week. The cumulative decreases in morning FEV_1, evening FEV_1, morning P£F and evening PEF associated with an interquartile range (35.8 µg/m~3) increase in PM_(2.5) concentrations were 33.49 [95% confidence interval-(CI):2.4S,54.S3] mL, 16.80 (95%CI：3.75,29.86) mL, 4.48 (95%CI：2.30,6.66) L/ min, and 1.31 (95%CI：-0.85,3.47) L/min, respectively. These results were not substantially changed after adjusting for gases in two-pollutant models. The associations of elemental carbon (EC) and nitrates with morning/evening FEV_1, and the associations of EC and sulfates with morning PEF were robust after controlling for PM_(2.5). This study demonstrated that short-term exposure to PM_(2.5) was associated with reduced pulmonary function. Some constituents (EC, sulfate and nitrate) may be responsible for the detrimental effects.
机译：关于引起肺功能障碍的细颗粒物质（PM_（2.5））的证据非常有限。我们设计了一项针对28位患者的时间序列面板研究，研究了2012年12月至2013年5月在中国上海进行的每日重复测量，研究了PM_（2.5）的10种主要成分对肺功能的影响。我们应用线性混合效应模型和分布式滞后模型来估计PM_（2.5）成分在1-s的早/晚强制呼气量（FEV_1）和一周内的最大呼气流量（PEF）上的累积效果。下午FEV_1，晚上FEV_1，早上P£F和晚上PEF的累积减少与四分位数范围（35.8 µg / m〜3）的PM_（2.5）浓度增加相关，为33.49 [95％置信区间-（CI）：2.4 S，54.S3] mL，16.80（95％CI：3.75,29.86）mL，4.48（95％CI：2.30,6.66）L / min和1.31（95％CI：-0.85,3.47）L / min，分别。在对两种污染物的模型中的气体进行校正后，这些结果没有实质性的改变。控制PM_（2.5）后，元素碳（EC）和硝酸盐与早晨/晚上FEV_1的关联以及EC和硫酸盐与早晨PEF的关联均很强。这项研究表明，短期暴露于PM_（2.5）与肺功能下降有关。某些成分（EC，硫酸盐和硝酸盐）可能是有害作用的原因。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第3期|1687-1694|共8页
  • 作者

    Shujing Chen; Yutong Gu; Liping Qiao; Cuicui Wang; Yuanlin Song; Chunxue Bai; Yuchun Sun; Haiying Ji; Min Zhou; Hongli Wang; Renjie Chen; Haidong Kan;

  • 作者单位

    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences, Shanghai 200233, China;

    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China;

    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    Medical Department, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;

    State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences, Shanghai 200233, China;

    State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences, Shanghai 200233, China;

    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China ,Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai 200433, China;

    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China ,Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai 200433, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号