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首页> 外文期刊>Environmental Science & Technology >Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development
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Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development

机译：蜕皮激素受体激动导致节肢动物致命蜕皮破坏：回顾和不良结果途径发展

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摘要

Molting is critical for growth, development, reproduction, and survival in arthropods. Complex neuroendocrine pathways are involved in the regulation of molting and may potentially become targets of environmental endocrine disrupting chemicals (EDCs). Based on several known ED mechanisms, a wide range of pesticides has been developed to combat unwanted organisms in food production activities such as agriculture and aquaculture. Meanwhile, these chemicals may also pose hazards to nontarget species by causing molting defects, and thus potentially affecting the health of the ecosystems. The present review summarizes the available knowledge on molting-related endocrine regulation and chemically mediated disruption in arthropods (with special focus on insects and crustaceans), to identify research gaps and develop a mechanistic model for assessing environmental hazards of these compounds. Based on the review, multiple targets of EDCs in the molting processes were identified and the link between mode of action (MoA) and adverse effects characterized to inform future studies. An adverse outcome pathway (AOP) describing ecdysone receptor agonism leading to incomplete ecdysis associated mortality was developed according to the OECD guideline and subjected to weight of evidence considerations by evolved Bradford Hill Criteria. This review proposes the first invertebrate ED AOP and may serve as a knowledge foundation for future environmental studies and AOP development.
机译：蜕皮对于节肢动物的生长，发育，繁殖和生存至关重要。复杂的神经内分泌途径参与蜕皮的调节，并可能成为环境内分泌干扰化学物质（EDC）的目标。基于几种已知的ED机制，已开发出多种农药来对抗食品生产活动（例如农业和水产养殖）中的有害生物。同时，这些化学物质还可能通过引起蜕皮缺陷而对非目标物种造成危害，从而潜在地影响生态系统的健康。本综述总结了关于蜕皮相关的内分泌调节和节肢动物中化学介导的破坏的可用知识（特别关注昆虫和甲壳类动物），以鉴定研究空白并建立评估这些化合物的环境危害的机理模型。在审查的基础上，确定了蜕皮过程中EDC的多个目标，并确定了作用方式（MoA）与不良影响之间的联系，以为以后的研究提供参考。根据OECD指南开发了描述蜕皮激素受体激动导致不完整的蜕皮病相关死亡率的不良结局途径（AOP），并根据不断发展的Bradford Hill标准对证据进行了权衡。这篇综述提出了第一个无脊椎动物ED AOP，并且可以作为未来环境研究和AOP开发的知识基础。

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  • 来源
    《Environmental Science & Technology》 |2017年第8期|4142-4157|共16页
  • 作者

    You Song; Daniel L. Villeneuve; Kenji Toyota; Taisen Iguchi; Knut Erik Tollefsen;

  • 作者单位

    Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalleen 21, N-0349 Oslo, Norway;

    US EPA Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, Minnesota 55804, United States;

    Environmental Genomics Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;

    Department of Basic Biology, Faculty of Life Science, SOKENDAI (Graduate University for Advanced Studies), Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan,Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan;

    Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalleen 21, N-0349 Oslo, Norway,Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), P.O. Box 5003, N-1432, As, Norway;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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