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首页> 外文期刊>Environmental Science & Technology >Re-evaluating the Significance of Estrone as an Environmental Estrogen
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Re-evaluating the Significance of Estrone as an Environmental Estrogen

机译：重新评估雌酮作为环境雌激素的重要性

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摘要

Studies worldwide have demonstrated the occurrence of feminized male fish at sites impacted by human and animal wastes. A variety of chemicals could contribute to this phenomenon, but those receiving the greatest attention in terms of research and monitoring have been 17β-estradiol (β-E2) and 17α-ethinylestradiol, due both to their prevalence in the environment and strong estrogenic potency. A third steroid, estrone (El), also can occur at high concentrations in surface waters but generally has been of lesser concern due to its relatively lower affinity for vertebrate estrogen receptors. In an initial experiment, male fathead minnow (Pimephales promelas) adults were exposed for 4-d to environmentally relevant levels of waterborne El, which resulted in plasma β-E2 concentrations similar to those found in reproductively active females. In a second exposure we used ~(13)C-labeled El, together with liquid chromatography-tandem mass spectrometry, to demonstrate that elevated β-E2 measured in the plasma of the male fish was indeed derived from the external environment, most likely via a conversion catalyzed by one or more 17β- hydroxysteroid dehydrogenases. The results of our studies suggest that the potential impact of El as an environmental estrogen currently is underestimated.
机译：全世界的研究表明，在受人类和动物废物影响的地点，女性化的雄性鱼类的发生。多种化学物质均可导致这种现象，但由于其在环境中的流行和强大的雌激素作用，在研究和监测方面受到最大关注的是17β-雌二醇（β-E2）和17α-炔雌醇。第三类固醇，雌酮（E1）也可以在地表水中高浓度存在，但由于对脊椎动物雌激素受体的亲和力较低，因此通常较少受到关注。在最初的实验中，雄性fat鱼（Pimephales promelas）成虫暴露于环境相关水平的水性El中4-d，导致血浆β-E2浓度与具有生殖活性的雌性中的浓度相似。在第二次曝光中，我们使用了〜（13）C标记的El以及液相色谱-串联质谱，以证明雄鱼血浆中测得的β-E2升高确实源自外部环境，最有可能是通过一种或多种17β-羟基类固醇脱氢酶催化的转化。我们的研究结果表明，目前低估了El作为环境雌激素的潜在影响。

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  • 来源
    《Environmental Science & Technology》 |2017年第8期|4705-4713|共9页
  • 作者

    Gerald T. Ankley; David Feifarek; Brett Blackwell; Jenna E. Cavallin; Kathleen M. Jensen; Michael D. Kahl; Shane Poole; Eric Randolph; Travis Saari; Daniel L. Villeneuve;

  • 作者单位

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    Badger Technical Services, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    Oak Ridge Institute of Science Education, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

    U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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