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Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

机译:空气污染和气候变化对人类世道过敏的影响:过敏原和佐剂的含量,相互作用和修饰

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摘要

Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochenucal reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.
机译:空气污染和气候变化是过敏性疾病负担增加的潜在驱动力。然而,空气污染物和气候参数可能影响过敏性疾病的分子机制是复杂而难以捉摸的。本文概述了空气污染,气候变化,过敏原,佐剂和免疫系统之间的物理,化学和生物相互作用,探讨了这些相互作用如何促进过敏症的发展。我们审查并综合了来自大气,气候和生物医学研究的主要发现。概述并讨论了当前的知识状态,未解决的问题以及未来的研究前景。人类时代是当今全球对地球以及人类环境的普遍性人为影响的时代,其特征是二氧化碳,臭氧,氮氧化物以及与燃烧或交通有关的颗粒物大量增加。大气层。这些环境因素可以提高人体的丰度并诱导其过敏原的化学修饰,增加人体的氧化压力,并使免疫系统偏向于过敏反应。尤其是,空气污染物可以充当佐剂并改变变应原性蛋白质的免疫原性,而气候变化会影响大气中的丰度以及人类对生物气溶胶和气变应原的暴露。为了充分理解和有效减轻空气污染和气候变化对过敏性疾病的不利影响,有几个挑战有待解决。其中包括在相关环境和生理条件下鉴定和定量涉及过敏原和佐剂的免疫化学反应途径。

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  • 来源
    《Environmental Science & Technology》 |2017年第8期|4119-4141|共23页
  • 作者单位

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany,Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg University, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany,Department of Chemistry, University of California, Irvine, California 92697-2025, United States;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany,South China University of Technology, School of Environment and Energy, Guangzhou, 510006, China;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, 55131, Germany;

    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, 55131, Germany;

    Division 1.5 Protein Analysis, Federal Institute for Materials Research and Testing (BAM), Berlin, 12489, Germany;

    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria;

    Institute of Translational Immunology and Research Center for Immunotherapy, Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, Mainz, 55131 Germany,Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States;

    Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, 55128, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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