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首页> 外文期刊>Environmental Science & Technology >Catbirds are the New Chickens: High Sensitivity to a Dioxin-like Compound in a Wildlife Species
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Catbirds are the New Chickens: High Sensitivity to a Dioxin-like Compound in a Wildlife Species

机译：bird是新型鸡：对野生物种中的二恶英类化合物具有较高的敏感性

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摘要

Dioxins and dioxin-like compounds (DLCs) are highly toxic and persistent global pollutants with extremely large differences in sensitivity across taxonomic groups. The chicken has long been considered uniquely sensitive to DLCs among avian species; but DLC toxicity in nondomesticated birds is largely untested, and the relevance of the chicken as an ecological model is uncertain. New approaches that use genotyping of the AHR1 ligand binding domain to screen for DLC sensitivity among avian species predicted that the gray catbird, a relevant wildlife species, is also highly sensitive. We tested this prediction using egg injections of a dioxin-like PCB (PCB-126) and found that the catbird is at least as sensitive as the chicken to DLCs, based on both embryotoxicity and mRNA induction of phase I metabolizing enzymes (CYP1A4/ 5). This study is the first to confirm that there are wildlife species as sensitive as the chicken and demonstrates how using predictive genotyping methods and targeted bioassays can focus toxicity assessments on ecologically relevant species.
机译：二恶英和类二恶英化合物（DLC）是高毒性和持久性全球污染物，在不同分类组之间的敏感性差异非常大。长期以来，人们一直认为这只鸡对禽类中的DLC具有独特的敏感性。但是未驯化的禽类中DLC的毒性在很大程度上未经测试，而且鸡作为生态模型的相关性还不确定。使用AHR1配体结合域的基因分型来筛选禽类动物DLC敏感性的新方法预测，作为相关野生动植物种的灰猫也高度敏感。我们使用鸡蛋注射二恶英样多氯联苯（PCB-126）检验了这一预测，并根据胚胎毒性和I期代谢酶的mRNA诱导（CYP1A4 / 5），发现the对DLC的敏感性至少与鸡一样。 ）。这项研究是第一个证实野生动植物物种与鸡一样敏感的研究，并证明了使用预测性基因分型方法和针对性生物测定法如何将毒性评估集中在与生态相关的物种上。

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  • 来源
    《Environmental Science & Technology》 |2017年第9期|5252-5258|共7页
  • 作者

    Margaret L. Eng; Christine A. Bishop; Doug Crump; Stephanie P. Jones; Tony D. Williams; Kenneth G. Drouillard; John E. Elliott;

  • 作者单位

    Science and Technology Branch, Environment and Climate Change Canada, 5421 Robertson Road, Delta, British Columbia V4K 3N2, Canada;

    Science and Technology Branch, Environment and Climate Change Canada, 5421 Robertson Road, Delta, British Columbia V4K 3N2, Canada;

    Science and Technology Branch, Environment and Climate Change Canada, 1125 Colonel By Drive, Raven Road, Ottawa, Ontario K1A 0H3, Canada;

    Science and Technology Branch, Environment and Climate Change Canada, 1125 Colonel By Drive, Raven Road, Ottawa, Ontario K1A 0H3, Canada;

    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada;

    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada;

    Science and Technology Branch, Environment and Climate Change Canada, 5421 Robertson Road, Delta, British Columbia V4K 3N2, Canada ,Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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