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首页> 外文期刊>Environmental Science & Technology >Global Proteome Profiling of a Marine Copepod and the Mitigating Effect of Ocean Acidification on Mercury Toxicity after Multigenerational Exposure
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Global Proteome Profiling of a Marine Copepod and the Mitigating Effect of Ocean Acidification on Mercury Toxicity after Multigenerational Exposure

机译：海洋Co足类动物的全球蛋白质组分析和多代暴露后海洋酸化对汞毒性的缓解作用

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摘要

Previously, we found that ocean acidification (OA) mitigates mercury (Hg) toxicity to marine copepod Tigriopus japonicus under multigenerational exposure (four generations, F0-F3). To determine the response mechanisms of T. japonicus against long-term exposure to OA and Hg pollution, we investigated the proteome of F3 copepods after multigenerational exposure to four conditions: pCO_2 400 μatm + control; pCO_2 1000 μatm + control; pCO_2 400 μatm +1.0 μg/L Hg; and pCO_2 1000 μatm +1.0 μg/L Hg. Functional enrichment analysis indicated that OA enhanced the copepods energy production mainly by increasing protein assimilation and proteolysis as a compensatory strategy, which explained its physiological resilience to reduced pH. Conversely, Hg treatment decreased many critical processes, including ferric iron binding, antioxidant activity, cellular homeostasis, and glutathione metabolism, and these toxic events could translate into higher-level responses, i.e., restrained reproduction in copepods. Importantly, the mediation of Hg toxicity in T. japonicus by OA could be explained by the enhanced lysosome-autophagy pathway proteomes that are responsible for repairing and removing damaged proteins and enzymes under stress. Overall, this study provided molecular insights into the response of T. japonicus to long-term exposure of OA and Hg, with a particular emphasis on the mitigating impact of the CO_2-driven acidification on Hg toxicity.
机译：以前，我们发现在多代暴露（四代，F0-F3）下，海洋酸化（OA）可以减轻汞对海洋co足类Tigriopus japonicus的毒性。为了确定日本血吸虫对长期暴露于OA和Hg污染的响应机制，我们研究了多代暴露于四种条件下的F3 pe足类的蛋白质组：pCO_2 400μatm+对照； pCO_2 1000μatm+对照； pCO_2 400μatm+1.0μg/ L汞;和pCO_2 1000μatm+1.0μg/ L Hg。功能富集分析表明，OA主要通过增加蛋白质同化和蛋白水解作为补偿策略来提高enhanced足类的能量产生，这解释了其对降低pH的生理适应性。相反，汞处理减少了许多关键过程，包括三价铁结合，抗氧化活性，细胞稳态和谷胱甘肽代谢，这些毒性事件可转化为更高水平的反应，即限制co足类的繁殖。重要的是，OA对日本血吸虫中Hg毒性的介导可以通过溶酶体自噬途径蛋白质组的增强来解释，该蛋白质组负责在压力下修复和去除受损的蛋白质和酶。总的来说，这项研究提供了对日本血吸虫对长期暴露于OA和Hg的响应的分子见解，尤其着重于减轻CO_2驱动的酸化对Hg毒性的影响。

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  • 来源
    《Environmental Science & Technology》 |2017年第10期|5820-5831|共12页
  • 作者

    Minghua Wang; Jae-Seong Lee; Yan Li;

  • 作者单位

    Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology,Xiamen University, Xiamen 361102, China,State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China;

    Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology,Xiamen University, Xiamen 361102, China,Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea;

    Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems/College of the Environment & Ecology,Xiamen University, Xiamen 361102, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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