...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China
【24h】

Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China

机译：暴露于环境中的微囊藻毒素增加了乙型肝炎病毒与黄曲霉毒素联合引起的肝损伤风险：西南地区的一项横断面研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Three liver hazards, two confirmed—hepatitis B virus (HBV) and aflatoxin (AFB), and one rarely studied in populations—microcystin (MC), simultaneously exist in tropical and humid areas; however, there are no epidemiological data on their risks in the same population. We conducted a community-based cross-sectional survey among 5493 adults in two rural towns and statistically analyzed the comparative and combinative effects of the three factors after detecting HBsAg and HBV DNA titers, determining estimated daily intakes (EDIs) of AFB1 and MC-LR and testing serum AST and ALT as liver injury markers for each participant. We observed a HBsAg(+) rate of 7.6%, a relatively high AFBJ exposure level (mean EDL_(AFBl) = 471.30 ng/d), and a relatively low MC-LR exposure level (mean EDI_(MC-LR) = 228.25 ng/d). ORs for abnormal AST (2.42, 95%CI = 1.69-3.45) and ALT (2.87, 95%CI = 1.91-4.29) increased in HBV infections compared with HBV-unexposed participants but did not increase in participants with separate or combined exposure to AFB1 and MC-LR (EDIs > mean). Meanwhile, after adjustment for confounding factors, means of AST and ALT and ORs of abnormal AST and ALT were successively elevated after exposure to HBV, HBV&AFB1 (or HBV&MC-LR), and HBV&AFB1&MC-LR, especially in the group with detectable HBV DNA (AST: OR = 11.38, 95%CI = 3.91-33.17; ALT: OR = 17.09, 95%CI = 5.36- 54.53). Notably, ORs for abnormal AST and ALT in the HBV exposed group were not significantly different from those in HBV&AFB1 or in the HBV&MC-LR exposed group but were significantly higher in the HBV&AFB1&MC-LR exposed group (P = 0.029 and P = 0.037, respectively). Our study indicated that microcystin may have the potential to increase the risk of liver injury induced by combined exposure to HBV and aflatoxin. However, in consideration of the uncertainties in the detection of the toxins and evaluation of the EDIs, more epidemiological data are expected to determine the increasing toxic effects of microcystins.
机译：在热带和潮湿地区同时存在三种肝脏危害，其中两种已被证实为乙型肝炎病毒（HBV）和黄曲霉毒素（AFB），另一种在人群中很少进行研究的微囊藻毒素（MC）。但是，没有关于同一人群中其危险性的流行病学数据。我们在两个农村城镇的5493名成年人中进行了基于社区的横断面调查，并在检测HBsAg和HBV DNA滴度，确定AFB1和MC-LR的估计每日摄入量（EDI）后，对这三个因素的比较和综合作用进行了统计分析并测试每位参与者的血清AST和ALT作为肝损伤的指标。我们观察到HBsAg（+）率为7.6％，较高的AFBJ暴露水平（平均EDL_（AFB1）= 471.30 ng / d），以及相对较低的MC-LR暴露水平（平均EDI_（MC-LR）= 228.25 ng / d）。与未接触HBV的受试者相比，HBV感染的AST（2.42，95％CI = 1.69-3.45）和ALT（2.87，95％CI = 1.91-4.29）异常的ORs增加，但单独或合并暴露于HBV的受试者的ORs没有增加AFB1和MC-LR（EDI>平均值）。同时，在调整混杂因素后，暴露于HBV，HBV＆AFB1（或HBV＆MC-LR）和HBV＆AFB1＆MC-LR后，尤其是在可检测到HBV DNA的人群中，AST和ALT的平均值以及AST和ALT异常的OR依次升高。 AST：OR ＝ 11.38，95％CI ＝ 3.91-33.17； ALT：OR ＝ 17.09，95％CI ＝ 5.36-54.53）。值得注意的是，HBV暴露组的AST和ALT异常的OR与HBV＆AFB1或HBV＆MC-LR暴露的组无显着差异，但在HBV＆AFB1＆MC-LR暴露的组中显着更高（分别为P = 0.029和P = 0.037 ）。我们的研究表明，微囊藻毒素可能会增加由HBV和黄曲霉毒素联合暴露引起的肝损伤风险。但是，考虑到毒素检测和EDI评估的不确定性，预计将有更多的流行病学数据确定微囊藻毒素的毒性增加。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第11期|6367-6378|共12页
  • 作者

    Wenyi Liu; Lingqiao Wang; Xiaohong Yang; Hui Zeng; Renping Zhang; Chaowen Pu; Chuanfen Zheng; Yao Tan; Yang Luo; Xiaobin Feng; Yingqiao Tian; Guosheng Xiao; Jia Wang; Yujing Huang; Jiaohua Luo; Lei Feng; Feng Wang; Changyou Yuan; Yuan Yao; Zhiqun Qiu; Ji-an Chen; Liping Wu; Qingqing Nong; Hui Lin; Weiqun Shu;

  • 作者单位

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    The Center for Disease Control and Prevention in Fuling District, Chongqing 408000, China;

    The Center for Disease Control and Prevention in Fuling District, Chongqing 408000, China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Transfusion Medicine, Southwest Hospital,Third Military Medical University, Chongqing 400038,China;

    Department of Transfusion Medicine, Southwest Hospital,Third Military Medical University, Chongqing 400038,China;

    The Center for Disease Control and Prevention in Fuling District, Chongqing 408000, China;

    College of Life Science and Engineering, Chongqing Three Gorges University, Wanzhou, Chongqing 404100, China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    The Center for Disease Control and Prevention in Fuling District, Chongqing 408000, China;

    The Township Central Hospital in Yihe Town, Fuling District, Chongqing 408104, China;

    'The Community Health Service Center in Lidu Town, Fuling District, Chongqing 408103, China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Institute of Hepatobiliary Surgery, Southwest Hospital,Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

    Department of Health Education, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China,Institute of Hepatobiliary Surgery, Southwest Hospital,Third Military Medical University, Chongqing 400038,China;

    Department of Tropical Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038,China;

    Department of Environmental Hygiene, College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号