...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Organophosphorus Flame Retardants in Pregnant Women and Their Transfer to Chorionic Villi
【24h】

Organophosphorus Flame Retardants in Pregnant Women and Their Transfer to Chorionic Villi

机译：孕妇中的有机磷阻燃剂及其向绒毛膜绒毛的转移

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The potential for prenatal exposure has recently raised concerns over the health risks of endocrine disruptors; however, knowledge about human prenatal exposure to organophosphorus flame retardants (OPFRs) is lacking. In this study, 2-ethylhexyl diphenyl phosphate (EHDPP), tributyl phosphate (TBP), triphenyl phosphate (TPHP), and tris(2-chloroethyl) phosphate (TCEP) were detected in the majority of chorionic villus samples, with median concentrations of 13.6, 18.8, 11.1, and 0.51 ng/g of dry weight (dw), respectively, significantly higher than those in the matching maternal decidua samples (5.96, 10.8,1.44, and 0.26 ng/g of dw, respectively). The ratios of concentrations in chorionic villi (containing embryos) to those in maternal deciduae (CMRs) were 4.17, 3.82, 2.81, and 2.00 for EHDPP, TPHP, TBP, and TCEP, respectively, which correlated with their log K_(ow) values (p = 0.003). The results of transthyretin (TTR) binding assays indicated that the stronger the binding ability to TTR, the higher the CMRs. The median concentrations of the metabolites diphenyl phosphate (DPHP), dibutyl phosphate (DBP), and bis(2- chloroethyl) phosphate (BCEP) were 4.11, 429, and 157 ng/g of dw in chorionic villi, higher than those in deciduae (1.64, 181, and 25.4 ng/g of dw, respectively). The ratios of DPHP/TPHP and DPHP/EHDPP were 0.20 and 0.43 in chorionic villi and 1.24 and 2.03 in deciduae, respectively, much lower than those of DBP/TBP and BCEP/TCEP (20.9 and 165.6 in chorionic villi and 13.1 and 35.3 in deciduae, respectively), suggesting that the difference in metabolism between the deciduae and chorionic villi would affect their maternal transfer.
机译：产前暴露的可能性最近引起了人们对内分泌干扰物健康风险的担忧。然而，缺乏关于人类产前接触有机磷阻燃剂（OPFRs）的知识。在这项研究中，在大多数绒毛膜绒毛样品中检测到2-乙基己基磷酸二苯酯（EHDPP），磷酸三丁酯（TBP），磷酸三苯酯（TPHP）和磷酸三（2-氯乙基）酯（TCEP），中位浓度为干重（dw）分别为13.6、18.8、11.1和0.51 ng / g，显着高于相匹配的母体蜕膜样品中的干重（dw）（分别为5.96、10.8、1.44和0.26 ng / g dw）。 EHDPP，TPHP，TBP和TCEP的绒毛膜绒毛（含胚胎）与母体十足动物（CMR）的浓度比分别为4.17、3.82、2.81和2.00，这与它们的log K_（ow）值相关（p ＝ 0.003）。转甲状腺素蛋白（TTR）结合测定的结果表明，与TTR的结合能力越强，CMR越高。绒毛膜绒毛中的代谢产物磷酸二苯酯（DPHP），磷酸二丁酯（DBP）和双（2-氯乙基）磷酸酯的中位浓度为4.11、429和157 ng / g dw，高于十亿分之一（分别为1.64、181和25.4 ng / g dw）。 DPHP / TPHP和DPHP / EHDPP的比率在绒毛膜绒毛中分别为0.20和0.43，在十足动物中分别为1.24和2.03，远低于DBP / TBP和BCEP / TCEP（绒毛膜绒毛中的20.9和165.6，绒毛膜绒毛中的13.1和35.3）分别表示，十足动物和绒毛膜绒毛之间的代谢差异会影响其母体转移。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第11期|6489-6497|共9页
  • 作者

    Fanrong Zhao; Mo Chen; Fumei Gao; Huan Shen; Jianying Hu;

  • 作者单位

    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People's Republic of China;

    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People's Republic of China;

    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People's Republic of China;

    Reproductive Medical Center, Peking University People's Hospital, Peking University, Beijing 100044, People's Republic of China;

    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号