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首页> 外文期刊>Environmental Science & Technology >Chlorinated Polyfluoroalkyl Ether Sulfonic Acids in Matched Maternal, Cord, and Placenta Samples: A Study of Transplacental Transfer
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Chlorinated Polyfluoroalkyl Ether Sulfonic Acids in Matched Maternal, Cord, and Placenta Samples: A Study of Transplacental Transfer

机译：匹配的母体，脐带和胎盘样品中的氯化多氟烷基醚磺酸：经胎盘转移的研究

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摘要

Currently, information regarding concentrations of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) in human placenta does not exist. The main objective of this study was to assess the occurrence and distribution of two Cl-PFESAs, 6:2 Cl-PFESA and 8:2 Cl-PFESA, in maternal serum, umbilical cord serum, and placenta to better assess the transport pathways related to human prenatal exposure. The widely studied perfluorooctanesulfonate (PFOS) was studied for comparison. This study was a hospital-based survey involving quantitative determination of Cl-PFESA and PFOS concentrations in maternal serum (n = 32), cord serum (n = 32), and placenta (n = 32) samples from women in Wuhan, China. The results indicate that Cl-PFESAs can efficiently be transported across placenta, with median exposure levels of 0.60 and 0.01 ng/mL for 6:2 Cl-PFESA and 8:2 Cl-PFESA in the cord sera, respectively. Concentrations of the target compounds in maternal sera, cord sera, and placentas decreased in the following order: PFOS > 6:2 Cl-PFESA > 8:2 Cl-PFESA Similar patterns were observed in maternal sera, cord sera, and placentas for Cl-PFESAs, with concentrations decreasing in the following order: maternal sera > cord sera > placentas. Significant correlations were observed among 6:2 Cl-PFESA, 8:2 Cl-PFESA, and PFOS concentrations in the maternal serum, cord serum, and placenta samples (r > 0.7; p < 0.001). The median value of R_(cm) (ratio of cord serum to maternal serum concentration) of 6:2 Cl-PFESA was 0.403, indicating a relatively high (~40%) placental transfer efficiency. 8:2 Cl-PFESA was transported across placenta to a greater extent than 6:2 Cl-PFESA was, likely because of its higher hydrophobicity and lower plasma protein binding affinity. To the best of our knowledge, this is the first study to report the occurrence and distribution of 6:2 Cl-PFESA and 8:2 Cl-PFESA in human placenta. The findings improve our understanding of the mechanisms of transplacental transfer and neonatal exposure to these important PFOS alternatives.
机译：当前，关于人胎盘中氯化多氟烷基醚磺酸（Cl-PFESAs）浓度的信息尚不存在。这项研究的主要目的是评估母体血清，脐带血清和胎盘中两种Cl-PFESA，6：2 Cl-PFESA和8：2 Cl-PFESA的发生和分布，以更好地评估相关的转运途径对人类产前暴露。为了进行比较，研究了广泛研究的全氟辛烷磺酸盐（PFOS）。这项研究是一项基于医院的调查，涉及定量测定中国武汉市孕妇血清（n = 32），脐带血清（n = 32）和胎盘（n = 32）中Cl-PFESA和PFOS的浓度。结果表明，Cl-PFESA可以有效地跨胎盘转运，脐带血清中6：2 Cl-PFESA和8：2 Cl-PFESA的中位暴露水平分别为0.60和0.01 ng / mL。母体血清，脐带血清和胎盘中目标化合物的浓度按以下顺序降低：PFOS> 6：2 Cl-PFESA> 8：2 Cl-PFESA在母体血清，脐带血清和胎盘中，Cl的模式相似-PFESAs，其浓度按以下顺序降低：母体血清>脐带血清>胎盘。在孕妇血清，脐带血清和胎盘样品中的6：2 Cl-PFESA，8：2 Cl-PFESA和PFOS浓度之间观察到显着相关性（r> 0.7; p <0.001）。 6：2 Cl-PFESA的R_（cm）（脐带血清与母体血清浓度的比率）的中值为0.403，表明胎盘转移效率相对较高（〜40％）。 8：2 Cl-PFESA比6：2 Cl-PFESA跨胎盘转运的程度更大，这可能是由于其较高的疏水性和较低的血浆蛋白结合亲和力。据我们所知，这是第一个报告6：2 Cl-PFESA和8：2 Cl-PFESA在人胎盘中的发生和分布的研究。这些发现增进了我们对胎盘转移和新生儿接触这些重要的全氟辛烷磺酸替代物的机制的了解。

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  • 来源
    《Environmental Science & Technology》 |2017年第11期|6387-6394|共8页
  • 作者

    Fangfang Chen; Shanshan Yin; Barry C. Kelly; Weiping Liu;

  • 作者单位

    Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    Department of Civil and Environmental Engineering, National University of Singapore, Singapore 117576;

    Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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