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首页> 外文期刊>Environmental Science & Technology >Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age
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Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

机译：线粒体基因组对长期环境微粒暴露与血液DNA甲基化年龄的关系的影响

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摘要

The mitochondrial genome has long been implicated in age-related disease, but no studies have examined its role in the relationship of long-term fine particle (PM_(2.5)) exposure and DNA methylation age (DNAm-age) - a novel measure of biological age. In this analysis based on 940 observations between 2000 and 2011 from 552 Normative Aging Study participants, we determined the roles of mitochondrial DNA haplogroup variation and mitochondrial genome abundance in the relationship of PM_(2.5) with DNAm-age. We used the GEOS-chem transport model to estimate address-specific, one-year PM_(2.5) levels for each participant. DNAm-age and mitochondrial DNA markers were measured from participant blood samples. Nine haplogroups (H, I, J, K, T, U, V, W, and X) were present in the population. In fully adjusted linear mixed-effects models, the association of PM_(2.5) with DNAm-age (in years) was significantly diminished in carriers of haplogroup V (P_(interaction) = 0.01; β = 0.18, 95%CI: -0.41, 0.78) compared to noncarriers (β = 1.25, 95%CI: 0.58, 1.93). Mediation analysis estimated that decreases in mitochondrial DNA copy number, a measure of mitochondrial genome abundance, mediated 12% of the association of PM_(2.5) with DNAm-age. Our data suggests that the mitochondrial genome plays a role in DNAm-age relationships particularly in the context of long-term PM_(2.5) exposure.
机译：线粒体基因组长期以来一直与年龄相关的疾病有关，但尚无研究检查其在长期微粒（PM_（2.5））暴露与DNA甲基化年龄（DNAm-age）之间的关系中的作用。生物学年龄。在这项分析的基础上，根据2000年至2011年间552名规范性衰老研究参与者的940项观察结果，我们确定了线粒体DNA单倍群变异和线粒体基因组丰度在PM_（2.5）与DNAm-age关系中的作用。我们使用GEOS-chem传输模型来估算每个参与者的特定于地址的一年PM_（2.5）水平。从参与者的血液样本中测量DNAmage和线粒体DNA标记。种群中存在9个单倍群（H，I，J，K，T，U，V，W和X）。在完全调整的线性混合效应模型中，单倍型V携带者中PM_（2.5）与DNAm-age的关联（以年为单位）显着降低（P_（相互作用）= 0.01；β= 0.18，95％CI：-0.41 （0.78），而非载体（β= 1.25，95％CI：0.58，1.93）。中介分析估计，线粒体DNA拷贝数（线粒体基因组丰度的一种度量）的降低介导了PM_（2.5）与DNAm-age关联的12％。我们的数据表明线粒体基因组在DNAm年龄关系中发挥作用，尤其是在长期PM_（2.5）暴露的情况下。

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  • 来源
    《Environmental Science & Technology》 |2017年第14期|8185-8195|共11页
  • 作者

    Nwanaji-Enwerem Jamaji C.; Colicino Elena; Dai Lingzhen; Cayir Akin; Sánchez-Guerra Marco; Laue Hannah E.; Nguyen Vy Thuy; Di Qian; Just Allan C.; Hou Lifang; Vokonas Pantel Steve; Coull Brent Andrew; Weisskopf Marc G.; Baccarelli Andrea A.; Schwartz Joel;

  • 作者单位

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States,Vocational Health College, Canakkale Onsekiz Mart University, Canakkale, Turkey;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States,Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States,Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States;

    Center for Population Epigenetics, Department of Preventive Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States;

    VA Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA, United States;

    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

    Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, United States;

    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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