...
首页> 外文期刊>Environmental Science & Technology >Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axis
【24h】

Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axis

机译:拟除虫菊酯杀虫剂氯氰菊酯通过破坏下丘脑-垂体-性腺轴促进雄性小鼠青春期发作。

获取原文
获取原文并翻译 | 示例
           

摘要

Pyrethroids, a class of insecticides that are widely used worldwide, have been identified as endocrine-disrupting chemicals (EDCs). Our recent epidemiological study reported on an association of increased pyrethroids exposure with elevated gonadotropins levels and earlier pubertal development in Chinese boys. In this study, we further investigated the effects of cypermethrin (CP), one of the most ubiquitous pyrethroid insecticides, on hypothalamic-pituitary-gonadal (HPG) axis and pubertal onset in male animal models. Early postnatal exposure to CP at environmentally relevant doses (0.5, 5, and 50 μg/kg CP) significandy accelerated the age of puberty onset in male mice. Administration of CP induced a dose-dependent increase in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone in male mice. CP did not affect gonadotropin-releasing hormone (GnRH) gene expression in the hypothalamus, but CP at higher concentrations stimulated GnRH pulse frequency. CP could induce the secretion of LH and FSH, as well as the expression of gonadotropin subunit genes [chorionic gonadotropin α (CGα), LHβ, and FSHβ] in pituitary gonadotropes. CP stimulated testosterone production and the expression of steroidogenesis-related genes [steroidogenic acute regulatory (StAR) and Cytochrome p 450, family 11, subfamily A, polypeptide 1 (CYP11A1)] in testicular Leydig cells. The interference with hypothalamic sodium channels as well as calcium channels in pituitary gonadotropes and testicular Leydig cells was responsible for CP-induced HPG axis maturation. Our findings established in animal models provide further evidence for the biological plausibility of pyrethroid exposure as a potentially environmental contributor to earlier puberty in males.
机译:拟除虫菊酯是一种在世界范围内广泛使用的杀虫剂,已被确定为破坏内分泌的化学物质(EDC)。我们最近的流行病学研究报告说,拟除虫菊酯暴露增加与促性腺激素水平升高和中国男孩青春期发育提前有关。在这项研究中,我们进一步研究了氯氰菊酯(CP),一种最普遍存在的拟除虫菊酯杀虫剂,对雄性动物模型的下丘脑-垂体-性腺(HPG)轴和青春期发作的影响。出生后早期以环境相关剂量(0.5、5和50μg/ kg CP)暴露于CP显着加快了雄性小鼠青春期发作的年龄。 CP的给药在雄性小鼠中诱导了血清促黄体生成激素(LH),促卵泡激素(FSH)和睾丸激素水平的剂量依赖性增加。 CP不会影响下丘脑中促性腺激素释放激素(GnRH)基因的表达,但是CP在较高浓度下会刺激GnRH脉冲频率。 CP可以诱导垂体促性腺激素分泌LH和FSH,以及促性腺激素亚基基因[绒毛膜促性腺激素α(CGα),LHβ和FSHβ]的表达。 CP刺激睾丸Leydig细胞中睾丸激素的产生和类固醇生成相关基因[类固醇生成的急性调节(StAR)和细胞色素p 450,家族11,亚家族A,多肽1(CYP11A1)]的表达。垂体促性腺激素和睾丸间质细胞对下丘脑钠通道和钙通道的干扰是CP诱导的HPG轴成熟的原因。我们在动物模型中建立的发现为拟除虫菊酯暴露作为男性早期青春期的潜在环境贡献者提供了生物学上的可行性。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第17期|10212-10221|共10页
  • 作者单位

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China,Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536, United States;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China,Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

    MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China,Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号