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首页> 外文期刊>Environmental Science & Technology >Elevated Exposures to Polycyclic Aromatic Hydrocarbons and Other Organic Mutagens in Ottawa Firefighters Participating in Emergency, On-Shift Fire Suppression
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Elevated Exposures to Polycyclic Aromatic Hydrocarbons and Other Organic Mutagens in Ottawa Firefighters Participating in Emergency, On-Shift Fire Suppression

机译：参与紧急，值班灭火的渥太华消防员的多环芳烃和其他有机诱变剂暴露量升高

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Occupational exposures to combustion emissions were examined in Ottawa Fire Service (OFS) firefighters. Paired urine and dermal wipe samples (i.e., pre- and post-event) as well as personal air samples and fire event questionnaires were collected from 27 male OFS firefighters. A total of 18 OFS office workers were used as additional controls. Exposures to polycyclic aromatic hydrocarbons (PAHs) and other organic mutagens were assessed by quantification of urinary PAH metabolite levels, levels of PAHs in dermal wipes and personal air samples, and urinary mutagenicity using the Salmonella mutagenicity assay (Ames test). Urinary Clara Cell 16 (CC16) and 15-isoprostane F_(2t) (8-iso-PGF_(2a)) levels were used to assess lung injury and overall oxidative stress, respectively. The results showed significant 2.9- to 5.3-fold increases in average post-event levels of urinary PAH metabolites, depending on the PAH metabolite (p < 0.0001). Average post-event levels of urinary mutagenicity showed a significant, event-related 4.3-fold increase (p < 0.0001). Urinary CC16 and 8-iso-PGF_(2a) did not increase. PAH concentrations in personal air and on skin accounted for 54% of the variation in fold changes of urinary PAH metabolites (p < 0.002). The results indicate that emergency, on-shift fire suppression is associated with significantly elevated exposures to combustion emissions.
机译：在渥太华消防局（OFS）的消防员中检查了燃烧排放的职业暴露。从27名男性OFS消防员中收集了成对的尿液和皮肤擦拭样品（即事前和事后）以及个人空气样品和火灾事件调查表。共有18名OFS办公室工作人员被用作其他控制人员。使用沙门氏菌诱变性测定法（Ames试验）通过定量尿中PAH代谢物水平，皮肤湿巾和个人空气样本中PAH的水平以及尿中的致突变性来评估多环芳烃（PAH）和其他有机诱变剂的暴露。尿克拉拉细胞16（CC16）和15-异前列腺素F_（2t）（8-iso-PGF_（2a））水平分别用于评估肺损伤和总体氧化应激。结果表明，取决于PAH代谢物，尿中PAH代谢物的平均事后水平显着增加了2.9到5.3倍（p <0.0001）。事件后尿液致突变性的平均水平显示出与事件相关的显着水平增加了4.3倍（p <0.0001）。尿CC16和8-iso-PGF_（2a）没有增加。个人空气和皮肤上PAH的浓度占尿中PAH代谢产物倍数变化的54％（p <0.002）。结果表明，紧急，按班制灭火与燃烧排放暴露量显着增加有关。

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  • 来源
    《Environmental Science & Technology》 |2017年第21期|12745-12755|共11页
  • 作者

    Jennifer L. A Keir; Umme S. Akhtar; David M. J. Matschke; Tracy L. Kirkham; Hing Man Chan; Pierre Ayotte; Paul A White; Jules M. Blais;

  • 作者单位

    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario KIN 6NS, Canada;

    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario KIN 6NS, Canada;

    Ottawa Fire Services, 1445 Carling Avenue, Ottawa, Ontario K1Z 7L9, Canada;

    Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada;

    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario KIN 6NS, Canada;

    Centre de toxicologic du Quebec, Institut national de sante publique du Quebec and Universite Laval, 945 Avenue Wolfe, Quebec City, Quebec G1V 5B3, Canada;

    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario KIN 6NS, Canada,Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario K1A 0K9, Canada;

    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario KIN 6NS, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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