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首页> 外文期刊>Environmental Science & Technology >Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)
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Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)

机译：长期饮食中硒代蛋氨酸的暴露会引起成年斑马鱼（丹尼奥里奥）的氧化应激，多巴胺能功能障碍和认知障碍。

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摘要

The present study was designed to investigate the effects of chronic dietary exposure to selenium (Se) on zebrafish cognition and also to elucidate possible mechanism(s) by which Se exerts its neurotoxicity. To this end, adult zebrafish were exposed to different concentrations of dietary L-selenomethionine (control, 2.3, 9.7, 32.5, or 57.7 μg Se/g dry weight) for 30 days. Cognitive performance of fish was tested using a latent learning paradigm in a complex maze. In addition, we also evaluated oxidative stress biomarkers and the expression of genes involved in dopaminergic neurotransmission in the zebrafish brain. Fish treated with higher dietary Se doses (32.5 and 57.5 μg Se/g) exhibited impaired performance in the latent learning task. The impaired learning was associated with the induction of oxidative stress and altered mRNA expression of dopamine receptors, tyrosine hydroxylase, and dopamine transporter genes in the zebrafish brain. Collectively, our results illustrate that cognitive impairment in zebrafish could be associated with Se-induced oxidative stress and altered dopaminergic neurotransmission in the brain.
机译：本研究旨在调查长期饮食中硒（Se）对斑马鱼认知的影响，并阐明硒发挥其神经毒性的可能机制。为此，将成年斑马鱼暴露于不同浓度的饮食中L-硒代蛋氨酸（对照，2.3、9.7、32.5或57.7μgSe / g干重），持续30天。在复杂的迷宫中，使用潜在学习范例对鱼的认知性能进行了测试。此外，我们还评估了氧化应激生物标记物和斑马鱼脑中多巴胺能神经传递相关基因的表达。饮食中添加较高硒含量（32.5和57.5μgSe / g）的鱼在潜伏学习任务中表现出受损。学习障碍与氧化应激的诱导和斑马鱼脑中多巴胺受体，酪氨酸羟化酶和多巴胺转运蛋白基因的mRNA表达改变有关。总体而言，我们的结果表明，斑马鱼的认知障碍可能与硒诱导的氧化应激和大脑中多巴胺能神经传递的改变有关。

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  • 来源
    《Environmental Science & Technology》 |2017年第21期|12879-12888|共10页
  • 作者

    Mohammad Naderi; Arash Salahinejad; Ankur Jamwal; Douglas P. Chivers; Som Niyogi;

  • 作者单位

    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada;

    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada;

    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada;

    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada;

    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada,Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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