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首页> 外文期刊>Environmental Science & Technology >Can Toxicokinetic and Toxicodynamic Modeling Be Used to Understand and Predict Synergistic Interactions between Chemicals?
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Can Toxicokinetic and Toxicodynamic Modeling Be Used to Understand and Predict Synergistic Interactions between Chemicals?

机译：毒物动力学和毒物动力学模型可以用来理解和预测化学物质之间的协同作用吗？

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摘要

Some chemicals are known to enhance the effect of other chemicals beyond what can be predicted with standard mixture models, such as concentration addition and independent action. These chemicals are called synergists. Up until now, no models exist that can predict the joint effect of mixtures including synergists. The aim of the present study is to develop a mechanistic toxicokinetic (TK) and toxicodynainic (TD) model for the synergistic mixture of the azole fungicide, propiconazole (the synergist), and the insecticide, alpha-cypermethrin, on the mortality of the crustacean Daphnia magna. The study tests the hypothesis that the mechanism of synergy is the azole decreasing the biotransformation rate of alpha-cypermethrin and validates the predictive ability of the model on another azole with a different potency: prochloraz. The study showed that the synergistic potential of azoles could be explained by their effect on the biotransformation rate but that this effect could only partly be explained by the effect of the two azoles on cytochrome P450 activity, measured on D. magna in vivo. TKTD models of interacting mixtures seem to be a promising tool to test mechanisms of interactions between chemicals. Their predictive ability is, however, still uncertain.
机译：已知某些化学品会增强其他化学品的作用，超出了标准混合物模型所能预测的范围，例如浓度增加和独立作用。这些化学物质称为增效剂。到目前为止，还没有模型可以预测包括增效剂在内的混合物的联合作用。本研究的目的是针对甲壳类杀真菌剂丙环唑（增效剂）和杀虫剂α-氯氰菊酯的协同混合物，建立甲壳类动物死亡率的机械毒性动力学（TK）和毒力动力学（TD）模型。水蚤。这项研究检验了以下假设：协同作用的机理是吡咯降低了α-氯氰菊酯的生物转化率，并验证了该模型对另一种效价不同的吡咯的前瞻性。研究表明，吡咯类化合物的协同潜力可以通过它们对生物转化率的影响来解释，但是这种作用只能部分地通过两种吡咯类化合物对体内D.magna的细胞色素P450活性的影响来解释。相互作用混合物的TKTD模型似乎是测试化学品之间相互作用机理的有前途的工具。但是，他们的预测能力仍然不确定。

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  • 来源
    《Environmental Science & Technology》 |2017年第24期|14379-14389|共11页
  • 作者

    Cedergreen Nina; Dalhoff Kristoffer; Li Dan; Gottardi Michele; Kretschmann Andreas C.;

  • 作者单位

    Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark;

    Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark;

    Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark;

    Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark;

    Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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