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首页> 外文期刊>Environmental Science & Technology >Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure
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Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure

机译：必需金属锌，硒和锶可防止多环芳烃暴露对染色体的损害

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摘要

Essential metals play important roles in maintaining cellular homeostasis, but the effects of their interaction with the environmental pollutants are still not very well-known in human subjects. The aim of this study was to evaluate the roles of essential metals and their interactions with polycyclic aromatic hydrocarbons (PAHs) on chromosome damage, an early carcinogenic event. A total of 1245 male workers were included in this study and the levels of 11 urinary essential metals, 12 urinary PAH metabolites, plasma concentrations of benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, and lymphocyte micronucleus (MN) frequencies were monitored. We found that zinc (Zn), selenium (Se), and strontium (Sr) have significant inverse dose-response relationships with MN frequencies (all P < 0.05). Furthermore, the protective roles of Zn, Se, and Sr were mainly shown among subjects with high levels of BPDE-Alb adducts. Significant effect modification of BPDE-Alb adducts on the associations of Zn, Se, and Sr with MN frequencies was observed (all P_(interaction) ＜ 0.05). Our study showed evidence that Zn, Se, and Sr play protective roles in reducing chromosome damage, and these effects can be modified by PAH exposure levels. These findings add potential evidence for the preventive effects of Zn, Se, and Sr against carcinogenesis in human subjects.
机译：必需金属在维持细胞体内平衡方面起着重要作用，但是它们与环境污染物相互作用的影响在人类受试者中仍然不是很清楚。这项研究的目的是评估必需金属的作用及其与多环芳烃（PAHs）相互作用对染色体损伤的早期致癌作用。这项研究总共包括1245名男性工人，其中11种尿必需金属，12种尿PAH代谢物的水平，苯并[a] pyrene-r-7，t-8，t-9，c-10-的血浆浓度监测四氢萘酚-白蛋白（BPDE-Alb）加合物和淋巴细胞微核（MN）频率。我们发现锌（Zn），硒（Se）和锶（Sr）与MN频率具有显着的剂量反比关系（所有P <0.05）。此外，Zn，Se和Sr的保护作用主要表现在BPDE-Alb加合物含量高的受试者中。观察到BPDE-Alb加合物对Zn，Se和Sr与MN频率的相关性有显着影响（所有P_（相互作用）＜0.05）。我们的研究表明有证据表明Zn，Se和Sr在减少染色体损伤中起保护作用，并且这些作用可以通过PAH暴露水平加以修正。这些发现为锌，硒和锶对人类受试者的致癌作用的预防作用提供了潜在的证据。

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  • 来源
    《Environmental Science & Technology》 |2016年第2期|951-960|共10页
  • 作者

    Yansen Bai; Wei Feng; Suhan Wang; Xiao Zhang; Wangzhen Zhang; Meian He; Xiaomin Zhang; Tangchun Wu; Huan Guo;

  • 作者单位

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Institute of Industrial Health, Wuhan Iron & Steel (Group) Corporation, Wuhan 430070, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

    Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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